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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 241-244.

• 综述与讲座 •    下一篇

加巴喷丁用于神经病理性疼痛治疗的研究进展

刘国凯, 黄宇光, 罗爱伦   

  1. 中国医学科学院中国协和医科大学北京协和医院麻醉科, 北京 100730
  • 收稿日期:2003-01-24 修回日期:2003-02-14 出版日期:2003-06-26 发布日期:2020-11-25
  • 通讯作者: 黄宇光, 男, 教授, 博士生导师, 中华医学会麻醉分会秘书,研究方向:疼痛基础和临床。Tel:010-65295580
  • 作者简介:罗爱伦, 女, 教授, 博士生导师, 中华医学会麻醉分会主任委员。刘国凯, 男, 在读博士研究生。E-mail:liouguokai@hotmail.com。

Research update of gabapentin in neuropathic pain management

LIU Guo-Kai, HUANG Yu-Guang, LUO Ai-Lun   

  1. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing 100730
  • Received:2003-01-24 Revised:2003-02-14 Online:2003-06-26 Published:2020-11-25

摘要: 研究表明加巴喷丁(gabapentin) 可作用于脊髓背角神经原突触后钙离子通道, 从而可能阻断了神经病理性疼痛产生的过程。临床证实加巴喷丁对糖尿病神经病变和带状疱疹后神经痛的治疗效果, 是治疗神经病理性疼痛有效的药物。

关键词: 药效学, 综述, 抗癫痫药, 加巴喷丁, 神经病理性疼痛

Abstract: Gabapentin may bind the α2δsubunit of the voltage-dependent calcium ion channels at the postsynaptic dorsal horn and interrupt the series of events possibly leading to the experience of a neuropathic pain sensation. Many clinical studies have clearly demonstrated the efficacy of gabapentin in the treatment of diabetic neuropathy and postherpetic neuralgia.Gabapentin is considered an effective drug with its minimal side effects and drug interactions in the management of neuropathic pain syndromes.

Key words: pharmacodynamics, review, anticonvulsant, gabapentin, neuropathic pain

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