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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 299-301.

• 研究原著 • 上一篇    下一篇

曲马多抑制全麻恢复期躁动反应及其量效和时效应的研究

陶明哲, 李少君, 白智萍, 黄小朋, 李涵葳   

  1. 暨南大学第二附属医院、深圳市人民医院麻醉科, 深圳 518020, 广东
  • 收稿日期:2002-12-25 修回日期:2003-01-03 出版日期:2003-06-26 发布日期:2020-11-25
  • 通讯作者: 陶明哲, 男, 医学硕士, 副主任医师, 中华医学会深圳麻醉专业学会委员兼秘书长, 研究方向:临床麻醉和术后疼痛治疗。Tel:0755-25533018-2592 E-mail:sina618@vip.sina.com

Inhibition of tramadol on restlessness and its dose-response and time-effect relationship in recovery period of general anesthesia

TAO Ming-Zhe, LI Shao-Jun, BAI Zhi-Ping, HUANG Xiao-Peng, LI Han-Wei   

  1. Department of Anesthesiology, Shenzhen People's Hospital &the Second Affiliated Hospital of Jinan University, Shenzhen 518020, Guangdong
  • Received:2002-12-25 Revised:2003-01-03 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 探讨曲马多对全麻恢复期躁动反应的影响及其量效和时效关系。方法: 138 例ASA Ⅰ ~Ⅲ级成年经腹手术患者, 实施异氟醚静吸复合插管全麻。双盲、随机分成空白对照组(34 例) 和用药组(104 例), 用药组分术毕前30 min 52 例和术毕时52例, 静注剂量均为1 mg·kg-1 和2 mg·kg-1 曲马多。观察麻醉恢复期呼吸循环和应激变化, 按Robertson法意识评分和Prince-Henry 疼痛评分, 记录躁动等不良反应发生率及程度。结果: 术毕前曲马多30 min组与对照组比较, 恢复期呼吸循环平稳(P <0.05),Prince-Henry 评分低(P <0.01), 躁动反应轻(P <0.05), 而术毕时与对照无差异, 且清醒时间延长;用药组意识水平低于对照组, 术毕时给药组更明显, 但各组的拔管时间无差异。结论: 1 ~ 2 mg·kg-1 曲马多术毕前静注能有效抑制全麻恢复期躁动反应, 其效应主要与给药时机有关。

关键词: 药效学, 静吸复合全麻, 恢复期, 曲马多, 并发症, 量效应, 时效应

Abstract: AIM: To study the effect of tramadol on restlessness in recovery period of general anesthesia and its dose-response and time-effect relationship. METHODS: 138 adult patients (ASA Ⅰ-Ⅲ) following abdominal surgery with isoflurane-balanced anesthesia were divided into 5 groups (a double-blind randomized study); control-group (n =34), T1 and T2 group (tramadol given 1 and 2 mg·kg -1, respectively, at the thirtieth minute before the end of operation, n =26), and T3 and T4 group (tramadol 1 and 2 mg·kg -1, respectively, at the end of operation, n =26).Some indices were observed including the changes of respiration and circulation, the conscious state with Robertson' s conscious scores and pain with Prince-Henry score, and the incidence and degree of adverse reaction. RESULTS: In comparison with control-group, the respiration and circulation were steady (P <0.05) in T1 and T2, with lower Prince-Henry score (P <0.01) and light restlessness, but that were not difference in T3 and T4.The time of extubation was not difference between each other, but consciousness level in the groups administered tramadol were lower than that in control group, and the lowest level existed at the end of operation in groups administered tramadol. CONCLUSION: Intravenous tramadol 1~2mg·kg -1 can effectively inhibit restlessness in recovery period of general anesthesia, but its effect is related to the time administered tramadol.

Key words: pharmacodynamics, intravenous-inhalation anesthesia, recovery period, tramadol, complication, dose-response relationship, time-effective relationship

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