药物新靶标非神经性乙酰胆碱系统的分布特征与功能1

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 361-365.

• 综述与讲座 • 下一篇

药物新靶标非神经性乙酰胆碱系统的分布特征与功能¹

李金菊, 汪海

军事医学科学院毒物药物研究所,北京 100850

收稿日期:2003-03-31 修回日期:2003-04-14 出版日期:2003-08-26 发布日期:2020-11-19
通讯作者: 汪海,男,研究员,博士生导师,从事心血管药理和新药研究。Tel:86-10-66932651 Fax:86-10-6821-1656 Email:wh@nic.bmi.ac.cn
作者简介:李金菊,女,博士研究生,副教授,主要从事分子心血管药理学研究。Tel:86-10-66931557 Fax:86-10-6821-1656 E-mail:Fanrz@163.com
基金资助:
1 国家重点基础研究发展规划项目(NoG1998051112);北京赛德维抗医药研究院新药研究基金项目(No199900)

Non-neuronal acetylcholine distributed and characteristics of function in biological system¹

LI Jin-Ju, WANG Hai

Institute ofPharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China

Received:2003-03-31 Revised:2003-04-14 Online:2003-08-26 Published:2020-11-19

摘要/Abstract

摘要： 非神经性乙酰胆碱系统(non-neuronal acetylcholine system,NNAs)广泛存在于各种非神经支配的组织或器官中。非神经性ACh,以自分泌或旁分泌方式,通过相应的受体参与细胞基本功能的调节,如基因表达、增生、分化、细胞骨架的组成、细胞间接触、细胞运动、迁移、液体的分泌与重吸收以及细胞的营养等功能,也对细胞因子的释放和系统急性炎症等方面具有重要调节作用。非神经性胆碱系统具有的广泛的生物学功能提示,非神经胆碱系统功能异常在一些疾病如炎症、动脉粥样硬化、局部及系统感染以及肿瘤等中具有重要的作用。因此,NNAs 已成为药物研究的新靶标。

关键词: 药理学, 非神经性乙酰胆碱系统, 生物学作用, 乙酰胆碱, 内皮细胞, 细胞功能

Abstract: ACh is widely expressed inPro- and eukaryotic non-neuronal cells.Non-neuronal ACh mediates its cellular actions in an auto-andParacrine manner via the activation of the widely expressed nicotinic and muscarinic acetylcholine receptors,which can interfere with virtually all cellular signallingPathways.Non-neuronal ACh appears to be involved in the regulation of basic cell functions,such as mitosis,cell differentiation,organization of the cytoskeleton,cell-cell contact,secretion,and absorption.Non-neuronal ACh alsoPlays a role in the regulation of immune functions.The involvement of the non-neuronal cholinergic system in thePathogenesis of variety of diseases should be investigated to open uPnew therapeutic strategies.

Key words: pharmacology, acetylcholine, the nonneuronal cholinergic system, function in biological system, endothelium, basic cell function

中图分类号:

李金菊, 汪海. 药物新靶标非神经性乙酰胆碱系统的分布特征与功能¹[J]. 中国临床药理学与治疗学, 2003, 8(4): 361-365.

LI Jin-Ju, WANG Hai. Non-neuronal acetylcholine distributed and characteristics of function in biological system¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(4): 361-365.

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药物新靶标非神经性乙酰胆碱系统的分布特征与功能¹

Non-neuronal acetylcholine distributed and characteristics of function in biological system¹

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