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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 385-388.

• 研究原著 • 上一篇    下一篇

万灵五香巴布膏活血通络与消肿止痛的药理作用

庞丹梅1, 郑晓亮, 唐建飞, 刘雪莉, 钱伯初   

  1. 浙江省医学科学院药物研究所,杭州 310013,浙江;
    1浙江大学药学院,杭州 310006,浙江
  • 收稿日期:2003-03-20 修回日期:2003-03-25 出版日期:2003-08-26 发布日期:2020-11-19
  • 通讯作者: 钱伯初,男,研究员,硕士生导师,研究方向:老年病与抗衰老药物研发。Tel:13958114545 E-mail:qianbochu@yahoo.com.cn
  • 作者简介:庞丹梅,女,硕士生,研究方向:抗炎镇痛新药研究。Tel:13858049959

Anti-inflammatory and analgesic effects of wanlingwuxiangPAPPatcher

PANG Dan-Mei1, ZHENG Xiao-Liang, TANG Jian-Fei, lIU Xue-Li, QIAN Bo-Chu   

  1. Institute of Materia Medica,Zhejiang Academy of Medical Sciences,Hangzhou 310013,Zhejiang,China;
    1College ofPharmacy,Zhejiang University,Hangzhou 210006,Zhejiang,China
  • Received:2003-03-20 Revised:2003-03-25 Online:2003-08-26 Published:2020-11-19

摘要: 目的 观察万灵五香巴布膏活血通络与消肿止痛的药理作用。方法 采用小鼠光热法与扭体法镇痛试验观察止痛作用;小鼠巴豆油耳肿胀试验与大鼠佐剂关节炎抗炎试验观察消肿作用;小鼠耳廓微循环试验和大鼠急性软组织损伤试验观察活血通络作用。结果 万灵五香巴布膏能显著提高小鼠光热法测得的痛阈和减少冰醋酸所致小鼠扭体反应次数;减轻巴豆油所致小鼠耳肿胀和大鼠佐剂性关节炎的肿胀度;改善小鼠耳廓微循环和减轻打击所致大鼠急性软组织损伤。结论 万灵五香巴布膏有明显的活血通络与消肿止痛药理作用。

关键词: 药理学, 万灵五香巴布膏, 抗炎, 镇痛, 佐剂关节炎

Abstract: AIM: To observe anti-inflammatory and analgesic effects of wanlingwuxiangPAPPatcher in rats and mice.METHODS: The anti-inflammatory effect was studied by adjuvant arthritis in rats and croton oil method in mice.The analgesic effect was detected by writhing with acetic acid andlight-hot methods.The soft tissue injury test in rats and normal skin microcirculation test in mice werePerformed according toliterature.RESULTS: Significant effects of wanlingwuxiangPAPPatcher on rats adjuvant arthritis induced by Freund' s complete adjuvant,mice ear swelling caused by croton oil,and marked analgesic action in mice were observed.It could also relieve acute soft tissue injury and improve ear microcirculation.CONCLUSION: WanlingwuxiangPAPPatcher has effects of anti-inflammatory,analgesic,improvement of ear microcirculation,and remission of soft tissue injury actions.

Key words: pharmacology, wanlingwuxiangPAPPatcher, anti-inflammatory, analgesia, adjuvant arthritis

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