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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 457-458.

• 研究原著 • 上一篇    下一篇

雌孕激素体内变化与产后抑郁的关系

罗来敏, 仇剑崟1, 梅丽萍, 徐芬芳   

  1. 上海交通大学附属第六人民医院妇产科,上海 200233;
    1上海市精神卫生中心,上海 200030
  • 收稿日期:2002-12-23 修回日期:2003-02-25 出版日期:2003-08-26 发布日期:2020-11-19

RelationshiPbetween changes of estrogen andProgesterone in vivo andPostpartum depression

LUOlai-Min, QIU Jian-Yin1, MEIli-Ping, XU Fen-Fan   

  1. Department of Gynecology and Obstetrics,the Sixth AffiliatedPeople' s Hospital,Shanghai Jiaotong University,Shanghai 200233,China;
    1Shanghai Mental Health Center,Shanghai 200030,China
  • Received:2002-12-23 Revised:2003-02-25 Online:2003-08-26 Published:2020-11-19

摘要: 目的 研究雌二醇(E2)、孕酮(P)、催乳素(PRL)产前产后的变化对产后抑郁的影响。方法 用放射免疫法测定38 例孕妇产程开始与产后72 h的E2 、P、PRL,同时用Edinburgh 产后抑郁量表(EPDS)、Beck 抑郁量表(BDI)、一般健康问卷(GHQ)在产后d3 与d42 进行评定。结果 产后d3 EPDS 与BDI 量表分显著高于产后d42(P<0.001)。产后E2 变化与EPDS 、BDI 量表分呈显著负相关,产后孕酮变化与产后d42 GHQ 量表分呈显著正相关,PRL变化不恒定。结论 产后雌激素水平过高、伴孕激素水平过低可能会诱发产后抑郁。

关键词: 药效学, 雌二醇, 孕酮, 催乳素, 产后抑郁

Abstract: AIM: To study the effects of changes of E2,PandPRL before and afterlabor onPostpartum depression.METHODS: The values of blood E2,PandPRL were measured by radio-immunity in 38 women at the beginning oflabor and at 72 h of thePostpartum.And these women were assessed with EPDS,BDI and GHQ at d 3 and d 42 of thePostpartum.RESULTS: The scores of EPDS and BDI at d 3 ofPostpartum were significantly higher than that atPostpartum d 42(P<0.001).The change ofPostpartum E2 was negatively related to the scores of EPDS and BDI,while the change ofPostpartumPwasPositively related to the scores of GHQ at d 42 of thePostpartum.CONCLUSION: Over-highPostpartum estrogen with verylowProgesterone mayPlay a role in thePostpartum depression.

Key words: pharmacodynamics, estradiol, progesterone, prolactin, postpartum depression

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