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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (5): 570-572.

• 研究原著 • 上一篇    下一篇

乌司他丁治疗急性胰腺炎的临床疗效评价

陈春雷, 陈曹臻, 林晖   

  1. 广东医学院第二附属医院普外科,湛江 524003,广东
  • 收稿日期:2003-03-03 修回日期:2003-04-03 出版日期:2003-10-26 发布日期:2020-11-19
  • 通讯作者: 陈春雷,医学学士,副主任医师,主要从事胃肠和肝胆疾病的临床研究。Tel:0759-2372290   E-mail:CHENG901230@21cn.com

Clinical evaluation on ulinastatin in treatment ofPatients with acutePan-creatitis

CHEN Chun-Lei, CHEN Cao-Zhen, LIN Hui   

  1. Department of General Surgery,Secondary Affiliated Hospital of Guangdong Medical College,Zhanjiang 524023,Guangdong,China
  • Received:2003-03-03 Revised:2003-04-03 Online:2003-10-26 Published:2020-11-19

摘要: 目的 观察乌司他丁(UTI)治疗急性胰腺炎(AP)的临床疗效 。方法 将 86例 AP患者随机分为UTI 治疗组(46 例)和甲磺酸加贝酯对照组(40 例)进行对比观察。结果 UTI 组总有效率 82.6%,明显优于甲磺酸加贝酯组的 65.0%(P<0.05)。治疗后除血糖外,两组患者的主要临床表现和实验室指标异常率皆比治疗前降低(P<0.05 或 0.01);UTI 组对腹痛、腹胀、恶心呕吐、发热 、上腹部压痛、反跳痛 、血尿淀粉酶、白细胞和 TB 等的恢复明显优于甲磺酸加贝酯组(P<0.05)。结论 UTI 是针对发病机理治疗 AP的一种价廉、高效、广谱及使用方便的酶抑制剂,无明显不良反应,值得临床推广应用。

关键词: 药效学, 乌司他丁, 急性胰腺炎, 甲磺酸加贝酯, 临床疗效

Abstract: AIM: To observe clinical effects of uli-nastatin (UTI)in treatment ofPatients with acutePancre-atitis (AP).METHODS: 86Patients withAPwere ran-domly divided into two groups:UTI treatment grouP(46cases)and gabexate mesylate control grouP(40 cases).RESULTS: Total effective rate had a significant differ-ence between UTI grouP(82.6%)and control group(65.0 %)(P<0.05).Except from blood sugar,main clinical symptoms andlab indices after treatment wereless than that before treatment (P<0.05 orP<0.01)in two groups.The therapeutic effects in UTI grouPwere better than those in control grouP(P<0.05)for releas-ing abdominal distention,nausea and vomit,fever,pressPain on epigastric region,bouncePain,amylase,white blood cells and TB,etc.CONCLUSIONS: UTI is an enzyme inhibitor in treatment ofPatients with acutePan-creatitis.

Key words: pharmacodynamics, ulinastatin, acutePancreatitis, gabexate mesylate, clinical effects

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