甲磺酸加替沙星与其他4 种氟喹诺酮类药物对临床分离菌的体外抗菌活性比较

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (1): 48-51.

甲磺酸加替沙星与其他4 种氟喹诺酮类药物对临床分离菌的体外抗菌活性比较

梁蓓蓓, 刘庆锋, 赵铁梅, 朱曼, 方翼, 王睿

解放军总医院临床药理研究室, 北京 100853

收稿日期:2003-07-14 修回日期:2003-08-14 出版日期:2004-01-26 发布日期:2020-11-16
通讯作者: 王睿,女, 教授, 硕士生导师, 研究方向:抗生素药理学研究。Tel:010-66937909 　E-mail: wangrui301 @95777.com
作者简介:梁蓓蓓, 女, 在读研究生。

Comparison of in vitro activity of gatifloxacin and other four fluoquinolones against clinical isolates

LIANG Bei-Bei, LIU Qing-Feng, ZHAO Tie-Mei, ZHU Man, FANG Yi, WANG Rui

Department of Clinical Pharmacology, the General Hospital of PLA, Beijing 100853, China

Received:2003-07-14 Revised:2003-08-14 Online:2004-01-26 Published:2020-11-16

摘要/Abstract

摘要： 目的: 比较甲磺酸加替沙星与氧氟沙星、左氧沙星、环丙沙星、司帕沙星对182 株临床分离菌的体外抗菌活性。方法: 采用琼脂平板二倍稀释法测定加替沙星等5 种氟喹诺酮类药物对182 株临床试验分离菌株的最低抑菌浓度(MIC) 。结果: 加替沙星对葡萄球菌属的MIC90比其他4 种氟喹诺酮类药物低。葡萄球菌属对加替沙星的敏感率显著高于其他4 种氟喹诺酮类药物;对其他G⁺球菌的MICR 也较其他氟喹诺酮类药物低。G^-杆菌中埃希菌属、肠杆菌属对加替沙星的敏感率明显高于其他4 种氟喹诺酮类药物, 加替沙星对埃希菌属、肠杆菌属的MIC90比左氧沙星低2 倍, 比其他3 种抗菌药物低8 倍;假单胞菌属、克雷伯菌属和其他G^-杆菌对加替沙星的敏感率与左氧沙星的差异无统计学意义, 与其他3 种氟喹诺酮类药物的差异有统计学意义。结论: 甲磺酸加替沙星具有广谱而强大的体外抗菌活性。

关键词: 加替沙星, 体外抗菌活性, 氟喹诺酮类, 临床分离菌

Abstract: AIM: To compare in vitro activity of gatifloxacin against 182 clinical isolated pathogens with those of ciprofloxacin, ofloxacin, levofloxacin and sparfloxacin.METHODS: The MICs of 182 clinical isolated pathogens were determined by the two-fold agar dilution method.RESULTS: The MIC90 of gatifloxacin against staphylococcus species was lower than the other four fluoquinolones. The ratio of sensitivity of staphylococcus species to gatifloxacin was higher than the other four fluoquinolones;the MICR of gatifloxacin against other gram-positive cocci was lower than the other four fluoquinolones.The ratios of sensitivity of gram-negative bacilli, such as Escherichia species and Enterobacter species to gatifloxacin were higher than the other four fluoquinolones;The MIC90 of gatifloxacin against escherichia species and enterobacter species was 2 fold lower than levofloxacin and 8 fold lower than the other 3 fluoquinolones.The ratios of sensitivity of pseudomonas species, klebsiella species and other gramnegative bacilli to gatifloxacin had no significance with levofloxacin and were higher than ciprofloxacin, ofloxacin, and sparfloxacin.CONCLUSION: In vitro activity of gatifloxacin against common clinical bacterium is strong.

Key words: gatif loxacin, in vitro activity, fluoquinolones, clinical isolates

中图分类号:

R978.1

梁蓓蓓, 刘庆锋, 赵铁梅, 朱曼, 方翼, 王睿. 甲磺酸加替沙星与其他4 种氟喹诺酮类药物对临床分离菌的体外抗菌活性比较[J]. 中国临床药理学与治疗学, 2004, 9(1): 48-51.

LIANG Bei-Bei, LIU Qing-Feng, ZHAO Tie-Mei, ZHU Man, FANG Yi, WANG Rui. Comparison of in vitro activity of gatifloxacin and other four fluoquinolones against clinical isolates[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(1): 48-51.

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