4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3, 3-二苯基)丙酯盐酸盐在小鼠的抗肿瘤作用

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (1): 59-62.

4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3, 3-二苯基)丙酯盐酸盐在小鼠的抗肿瘤作用

郭维, 冉福香, 王瑞卿, 崔景荣, 李润涛¹, 程铁明¹, 葛泽梅¹

北京大学天然药物及仿生药物国家重点实验室, 北京 100083;
¹北京大学药学院化学生物学系, 北京 100083

收稿日期:2003-07-02 修回日期:2003-07-18 出版日期:2004-01-26 发布日期:2020-11-16
通讯作者: 崔景荣,女, 教授, 硕士生导师, 研究方向:抗肿瘤和免疫调节剂药物筛选, 药效学和药物作用机制研究。Tel Fax:010-62092467 　E-mail: jrcui@mail.bjmu.edu.cn
作者简介:郭维, 女, 本科, 讲师, 研究方向:抗肿瘤药物的研究。李润涛, 男, 教授, 博士生导师, 研究方向:主要从事杂环化合物的合成及生物活性研究。
基金资助:
国家自然基金资助项目(NO.20172006); 国家重点科技项目(NO.96-901-02-08)

Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester

GUO Wei, RAN Fu-Xiang, WANG Rui-Qing, CUI Jing-Rong, LI Run-Tao¹, CHENG Tie-Ming¹, GE Ze-Mei¹

National Research Laboratory of Natural and Biomimetic Drugs, Beijing 100083, China;
¹Department of Chemical Biologz School of Pharmaceutic Sciences, Beijing Univiersity, Beijing 100083, China

Received:2003-07-02 Revised:2003-07-18 Online:2004-01-26 Published:2020-11-16

摘要/Abstract

摘要： 目的: 观察4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3, 3-二苯基) 丙酯盐酸盐(Hyd) 对小鼠移植性肿瘤的抑制作用, 以确定该化合物的应用前景。方法: 采用小鼠肉瘤180 和肝癌22 及人胃癌异种移植裸鼠肿瘤模型, 观察Hyd 对小鼠移植性肿瘤生长的影响。结果: 通过口服灌胃给药, 不同浓度Hyd 对小鼠移植性肉瘤S180抑制率可达到46.4 %~ 59.6 %(P<0.01 ~ 0.001);对小鼠移植性肝癌H22抑制率可达到39.3 %~ 51.6 %(P<0.05 ~ 0.001);对裸鼠人胃癌异种移植瘤的抑制率可达到18.1 %~ 59.0 %。结论: Hyd 对小鼠移植性肝癌H22 和小鼠移植性肉瘤S180有明显抑制作用, 对人胃癌裸小鼠异种移植性肿瘤也有明显抑制作用。

关键词: 4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3, 3-二苯基) 丙酯盐酸盐, 肉瘤S180, 肝癌H₂₂, 人胃癌异种移植性肿瘤

Abstract: AIM: To study the inhibition effects of the hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester (Hyd) on the growth of transplant carcinoma in mice.METHODS: The growth of tumor was observed by models of transplant tumor in mice.RESULTS: The inhibition rates of Hyd against tumor growth of S180 and H22 implanted human gastric carcinoma were 46.4 %-59.6 %, 39.3 %-51.6 % and 18.1 %-59.0 %, respectively in nude mice.CONCLUSION: Hyd can inhibit the growth of transplanted hepatocyte carcinoma 22, sarcoma 180 in mice, and implanted human gastric carcinoma in mice and nude mice.

Key words: hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester, sarcoma 180, hepatocyte carcinoma 22, implanted human gastric carcinoma

中图分类号:

R979.1
R965

郭维, 冉福香, 王瑞卿, 崔景荣, 李润涛, 程铁明, 葛泽梅. 4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3, 3-二苯基)丙酯盐酸盐在小鼠的抗肿瘤作用[J]. 中国临床药理学与治疗学, 2004, 9(1): 59-62.

GUO Wei, RAN Fu-Xiang, WANG Rui-Qing, CUI Jing-Rong, LI Run-Tao, CHENG Tie-Ming, GE Ze-Mei. Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(1): 59-62.

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