增乳方对左旋多巴诱导的哺乳大鼠低泌乳素血症的逆转作用

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (1): 77-79.

增乳方对左旋多巴诱导的哺乳大鼠低泌乳素血症的逆转作用

李琳, 杨淑琴, 孙莉莎, 徐江平

第一军医大学基础部药理教研室, 广州 510515, 广东

收稿日期:2003-06-13 修回日期:2003-07-16 出版日期:2004-01-26 发布日期:2020-11-16
通讯作者: 徐江平,男, 博士, 副教授, 研究方向:神经药理学。Tel:020-61648236 E-mail: xujp@fimmu.com
作者简介:刘蔚, 女, 主管药师, 在读博士生, 现工作单位:解放军309 医院临床药理科。Tel:010-66775099 　E-mail: weiliu528 @hotmail.com

Reverse effects of composite lactogenic decoction on hypoprolactinemia induced by L-dopa in rats

LI Lin, YANG Shu-Qin, SUN Li-Sha, XU Jiang-Ping

Department of Pharmacology, the First Military Medical University, Guangzhou 510515, Guangdong, China

Received:2003-06-13 Revised:2003-07-16 Online:2004-01-26 Published:2020-11-16

摘要/Abstract

摘要： 目的: 研究增乳方(CLD) 对左旋多巴诱导的低泌乳素血症哺乳大鼠乳汁分泌的促进作用。方法: 采用左旋多巴(L-Dopa) 诱导建立哺乳大鼠乳汁分泌低下模型;大鼠ig 给予CLD, 观察不同剂量(3 、6 、20 g·kg^-1·d^-1) CLD 对哺乳期大鼠的仔鼠体重以及母鼠血清泌乳素(PRL) 和乳腺组织学的影响。结果: 大鼠给予CLD 3 、6 、20 g·kg^-1 ·d^-1, 血清PRL 值显著高于模型组(P<0.05, P<0.01), 呈量-效关系;CLD 可明显增加母鼠泌乳量, 促进仔鼠体重的增长(P<0.05) 并促进母鼠乳腺的发育。结论: CLD对L-Dopa 诱导的哺乳大鼠低泌乳素血症具有逆转作用, 且促进乳汁的分泌。

关键词: 增乳方, 左旋多巴, 低泌乳素血症, 泌乳素

Abstract: AIM: To study the effects of the composite lactogenic decoction (CLD) on milk secretion of hypoprolactinemia induced by L-dopa in rats.METHODS: The models of hypoprolactinemia were established with Ldopa in rats. The weight of young rats was recorded during 15 days. Levels of serum prolactin were detected by ELISA and the mammary gland histology was observed by electron microscop.RESULTS: The administration of CLD (3, 6 and 20 g ·kg^-1) by the way of ig increased serum prolactin (PRL) level significantly (P<0.05 or 0.01) induced by L-dopa in rats at a dose-dependent manner.CLD increased the weight of young rats (P<0.05) and promoted the mammary grand growth of rats.CONCLUSION: CLD can reverse the symptom of hypoprolactinemia induced by L-dopa and promote the secretion of milk in rats.

Key words: composite lactogenic decoction, L-dopa, hypoprolactinemia, prolactin

中图分类号:

R285.5

李琳, 杨淑琴, 孙莉莎, 徐江平. 增乳方对左旋多巴诱导的哺乳大鼠低泌乳素血症的逆转作用[J]. 中国临床药理学与治疗学, 2004, 9(1): 77-79.

LI Lin, YANG Shu-Qin, SUN Li-Sha, XU Jiang-Ping. Reverse effects of composite lactogenic decoction on hypoprolactinemia induced by L-dopa in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(1): 77-79.

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