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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (1): 87-91.

• 研究原著 • 上一篇    下一篇

盐酸氮卓斯汀对豚鼠实验性哮喘的作用及其机理研究

蒋诗琴, 余光清1   

  1. 湖北省郧阳医学院药理学教研室, 1学报编辑部, 十堰 442000, 湖北
  • 收稿日期:2003-05-21 修回日期:2003-06-21 出版日期:2004-01-26 发布日期:2020-11-16
  • 通讯作者: 蒋诗琴,女, 硕士, 讲师, 从事心血管药理及临床药理学研究。Tel:0719-8891139-805 E-mail: Jiangsq5262@sina.com

Effect of azelastine hydrochloride on experimental asthma and its mechanism in guinea pigs

JIANG Shi-Qin, YU Guang-Qing1   

  1. Department of Pharmacology, 1Editorial Board of Journal, Yunyang Medical College, Shiyan 442000, Hubei, China
  • Received:2003-05-21 Revised:2003-06-21 Online:2004-01-26 Published:2020-11-16

摘要: 目的: 观察盐酸氮卓 斯汀(azelastine hydrochloride,AZ) 对豚鼠实验性哮喘的作用, 并探讨其作用机制。方法: 采用组胺和乙酰胆碱诱发在体豚鼠实验性哮喘模型, 观察AZ的整体作用;采用豚鼠离体气管螺旋条, 观察AZ对组胺所致的豚鼠离体气管螺旋条痉挛的拮抗作用。结果: AZ 能够剂量依赖性地拮抗组胺和乙酰胆碱的引喘作用, 明显延长引喘潜伏期, 显著减少抽搐动物发生率, 其ED50为0.216 mg·kg-1,95 %可信限为0.214 ~ 0.219 mg·kg-1 。AZ 可剂量依赖性地拮抗组胺对离体气管平滑肌的收缩作用, 使组胺量效曲线平行右移, 其pA2 值为8.99 。结论: 预先给予AZ能显著拮抗组胺和乙酰胆碱所诱发的在体豚鼠实验性哮喘, 抑制组胺所致的气管螺旋条收缩。

关键词: 盐酸氮卓斯汀, 哮喘, 组胺, 扑尔敏, 豚鼠

Abstract: AIM: To probe the effect of azelastine hydrochloride on experimental asthma and its mechanism.METHODS: Experimental asthma models of guinea pigs induced by histamine and acetylcholine in vivo as well as guinea-pig tracheal spirals in vitro were used in this experiment.RESULTS: Azelastine hydrochloride inhibited asthma induced by histamine and acetylcholine in guinea pigs in a dose-dependent manner, prolonged the incubation period of histamine and acetylcholine induced asthma (P<0.05), and decreased the rate of tic of guinea pigs.The mean effective dose (ED50) was 0.216 mg·kg-1 and its 95 %of confidence limit was from 0.214 to 0.219 mg·kg-1.Azelastine hydrochloride also apparently inhibited the bronchi muscle contraction induced by histamine in a dose-dependent manner and caused histamine dose-effect curve a right shift, and the pA2 was 8.99.CONCLUSION: Azelastine hydrochloride can significantly inhibit the experimental asthma induced by histamine and acetylcholine.

Key words: azelastine hydrochloride, asthma, histamine, chlorpheniramine maleate, guinea pigs

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