神经生长因子颅内注射治疗颅内血肿微创清除术后高血压性脑出血的疗效评价

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (10): 1150-1153.

神经生长因子颅内注射治疗颅内血肿微创清除术后高血压性脑出血的疗效评价

李军荣, 曹辉¹, 李学平, 杨文娟, 钱继跃

南京市江宁医院内科, 南京211100, 江苏;1南京脑科医院神经内科, 南京210029, 江苏

收稿日期:2004-07-01 修回日期:2004-09-06 出版日期:2004-10-26 发布日期:2020-11-23
通讯作者: 李军荣, 男, 学士, 副主任医师, 主要从事脑血管病研究。Tel:13327738522 E-mail:caohui6345@163. com

Efficacy of intracranial injection of the nerve growth factor (NGF) in treatment of patients with hypertensive cerebral hemorrhage after intracranial hemorrhage mini-invasive drainage

LI Jun-Rong, CAO Hui¹, LI Xue-Ping, YANG Weng-Juan, QIAN Ji-Yue

Nanjing Jiangning Hospital, Nanjing 211100, Jiangsu, China;
¹Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China

Received:2004-07-01 Revised:2004-09-06 Online:2004-10-26 Published:2020-11-23

摘要/Abstract

摘要： 目的: 对神经生长因子颅内注射治疗颅内血肿微创清除术后高血压性脑出血的疗效进行评价。方法: 将90 例颅内血肿微创清除术后的高血压性脑出血患者随机分为3 组, 每组30 例:对照组, 微创清除术后每日给予生理盐水2 ml 颅内注射, 4 d 后改为每日注射用水2 ml 肌注;治疗1 组, 微创清除术后每日给予生理盐水2 ml 颅内注射, 4 d 后改为每日神经生长因子2 ml 肌肉注射;治疗2 组, 微创清除术后每日给予神经生长因子2 ml 颅内注射, 4 d后改为每日神经生长因子2 ml 肌肉注射, 3 组疗程均为14 d 。采用卒中临床神经功能缺损评分、日常生活活动(ADL) 量表评分及死亡率等方法对治疗1月后进行疗效评定。结果: 3 组病例死亡率分别为对照组(13. 3 %) 、治疗1 组(10. 0 %) 、治疗2 组(10. 0 %) (P >0. 05); 治疗1 组和治疗2 组的显效率和总有效率分别为(40 %, 66. 67 %) 和(70 %, 80 %), 比对照组(20 %、36. 67 %) 高(P<0. 05); 治疗1 组和治疗2 组ADL 量表评分比对照组好(P<0. 05) 。结论: 神经生长因子能提高颅内血肿微创清除术后高血压性脑出血的临床疗效, 降低致残率, 明显提高病人的生活质量, 颅内注射效果更好。

关键词: 神经生长因子, 微创, 高血压性脑出血, 疗效评价

Abstract: AIM: To evaluate the efficacy of intracranial injection of the nerve growth factor (NGF) in treatment of patients with hypertensive cerebral hemorrhage after intracranial hemorrhage mini-invasive drainage.METHODS: 90 hypertentive cerebral hemorrhage patients after intracranial hemorrhage mini-invasive drainage were divided into three groups:Group A (n =30), patients were intracranial injected with 2 ml normal saline per day for 4 days, and then intracranial injected with 2 ml water per day for 10 days; Group B (n =30), patients were intracranial injected with 2 ml normal saline per day for 4 days, and then intracranial injected with 2 ml NGF per day for 10 days; Group C (n =30), patients were intracranial injected with 2 ml NGF per day for 4 days, and then intracranial injected with 2 ml NGF per day for 10 days. The curative effect was evaluated by neurological function scoring, ADL scoring and mortality after 1 month therapy.RESULTS: There was no significant difference on mortality in group A (13. 3 %), group B (10. 0 %) and group C (10. 0 %). The effective rates in group B (40 %) and group C (70 %) were higher than that in group A (20 %) (P<0. 05), and the total effective rate in group B (66. 67 %) and group C (80 %) were higher than that in group A (36. 67 %) (P<0. 05). Meanwhile, the values of ADL scoring were more significantly increased in group B and group C than that in group A.CONCLUSION: NGF can increase the clinical curative effect and decrease the disability rate in patients with hypertensive cerebral hemorrhage, and it can obviously improved the patient' s life quality. Furthermore, the effect of intracranial injection of NGF is marked.

Key words: mini-invasive drainage, hypertensive cerebral hemorrhage, nerve growth factor (NGF), curative effect evaluation

中图分类号:

李军荣, 曹辉, 李学平, 杨文娟, 钱继跃. 神经生长因子颅内注射治疗颅内血肿微创清除术后高血压性脑出血的疗效评价[J]. 中国临床药理学与治疗学, 2004, 9(10): 1150-1153.

LI Jun-Rong, CAO Hui, LI Xue-Ping, YANG Weng-Juan, QIAN Ji-Yue. Efficacy of intracranial injection of the nerve growth factor (NGF) in treatment of patients with hypertensive cerebral hemorrhage after intracranial hemorrhage mini-invasive drainage[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(10): 1150-1153.

[1]	陈峰，邹懿，胡波，胡松，陈勇，高大新. 鼠神经生长因子对坐骨神经痛大鼠背根神经节磷酸化p38MAPK表达的影响[J]. 中国临床药理学与治疗学, 2019, 24(4): 411-417.
[2]	蒋豪明，陈翔，李珍，顾承萍. 单唾液酸四己糖神经节苷脂联合鼠神经生长因子对新生儿缺氧缺血性脑病的临床研究[J]. 中国临床药理学与治疗学, 2019, 24(3): 301-306.
[3]	江爱娟，申国明，王浩，李道卫，王芹，何莹. 益气活血通络方对糖尿病周围神经病变大鼠背根神经节p75NTR和TrkA表达的影响[J]. 中国临床药理学与治疗学, 2016, 21(2): 121-124.
[4]	唐杰, 胡伟, 吴繁荣, 葛金芳, 潘春晓, 高文凡, 陈飞虎. 酸性条件下神经生长因子对大鼠关节软骨细胞酸敏感离子通道1a表达的影响[J]. 中国临床药理学与治疗学, 2015, 20(10): 1081-1086.
[5]	陈再丰, 许信龙, 魏晓捷, 傅小君, 潘红松, 谢青松. 鼠神经生长因子诱导骨髓间充质干细胞向神经元样细胞分化的实验研究[J]. 中国临床药理学与治疗学, 2012, 17(2): 137-140.
[6]	王海波, 吴式琇, 黄庆科. 比较中西医疗效评价方法在胃癌治疗应用中的差异[J]. 中国临床药理学与治疗学, 2011, 16(10): 1169-1173.
[7]	张小东, 刘建文, 李婷, 曹艳, 郭明川. 胡黄连甙Ⅱ和神经生长因子对H₂O₂ 损伤的PC12 细胞的协同保护作用[J]. 中国临床药理学与治疗学, 2007, 12(1): 32-37.
[8]	刘莉, 杨国成, 刘少平, 孟祥平, 高兴华, 汤贝贝. NGF 和神经节苷脂 GM₁ 对 2, 5-己二酮中毒性 PC12 细胞的协同保护作用[J]. 中国临床药理学与治疗学, 2006, 11(2): 173-177.
[9]	李涛. 中药治疗头痛的临床试验设计[J]. 中国临床药理学与治疗学, 2005, 10(5): 590-593.
[10]	李涛. 脑梗死中药临床试验的纳入标准与疗效评估中的若干思考[J]. 中国临床药理学与治疗学, 2005, 10(12): 1430-1433.
[11]	陈协兴, 洪华山, 陈良龙, 王一波, 叶明芳, 江琼. 螺内酯对慢性心力衰竭患者心功能及血清脑利钠肽水平的影响[J]. 中国临床药理学与治疗学, 2004, 9(4): 447-450.
[12]	曹辉, 管青山. 托吡酯单药治疗不同类型癫痫的疗效评价[J]. 中国临床药理学与治疗学, 2003, 8(6): 677-679.
[13]	李见春, 李娟, 田学丰. 潘托拉唑与其他药物治疗消化性溃疡对照研究Meta分析[J]. 中国临床药理学与治疗学, 2003, 8(6): 696-698.
[14]	熊宁宁, 罗玫, 蒋萌, 刘芳, 邹建东, 符为民. 中药临床试验的适应证侯设计与疗效评价[J]. 中国临床药理学与治疗学, 2003, 8(6): 715-717.
[15]	张中军, 李亚丽, 郭继龙. 静脉与硬膜外泵注芬太尼病人自控镇痛的疗效评价[J]. 中国临床药理学与治疗学, 2003, 8(5): 561-563.