胆碱对小鼠中枢镇痛效应的特征

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (11): 1217-1220.

胆碱对小鼠中枢镇痛效应的特征

苏冬梅¹, 刘跃¹, 王越^1,2, 王汝欢³, 汪海¹

¹军事医学科学院毒物药物研究所,北京 100850;
²山东大学医学院,济南 250012,山东;
³赛德维康医药研究院,北京 100850

收稿日期:2004-07-13 修回日期:2004-08-24 出版日期:2004-11-26 发布日期:2020-11-19
通讯作者: 汪海,男,教授,博士导师,研究方向为:神经药理学与心血管药理学:Tel: 010-66932651 E-mail:wh@nic.bmi.ac.cn
作者简介:苏冬梅,女,硕士,研究方向为神经药理学。
基金资助:
国家自然科学基金资助项目(No30371641);北京赛德维康医药研究院新药研究基金项目资助(No1999001)

Characteristics of antinociceptive effects of choline in central nervous system in mice

SU Dong-Mei¹, LIU Yue¹, WANG Yue¹², WANG Ru-Huan³, WANG Hai¹

¹Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;
²Medicine College of Shandong University,Jinan 250012, Shandong, China;
³Thadweik Academy of Medicine, Beijing 100850, Chirm

Received:2004-07-13 Revised:2004-08-24 Online:2004-11-26 Published:2020-11-19

摘要/Abstract

摘要： 目的: 研究胆碱中枢镇痛效应的药效学特征。方法: 通过小鼠热板实验观察不同剂量胆碱的镇痛作用及多种拮抗剂对其镇痛作用的影响,探讨胆碱镇痛作用的可能途径。结果: 胆碱（90~120 μg/只）可以产生镇痛作用,且能被MLA(50 μg/只）、α-银环蛇毒素（2 μg/只）和阿托品（0.1 μg/只）所拮抗,但不能被美加明（5 μg/只）和纳洛酮（2 μg/只）所拮抗。结论: 胆碱镇痛作用可能通过α₇烟碱受体亚型介导,且可能与M受体有关。

关键词: N受体激动剂, 胆碱, α₇烟碱受体亚型, 镇痛, 热板实验

Abstract: AIM: To investigate the characteristics of the antinociceptive effects of choline in central nervous system (CNS) in mice. METHODS: Hot-plate test (icv) was used to study the antinociceptive effects of cho-line, the influences of many antagonists on the antinoci-ceptive effects of choline were observed, the potential mechanisms underlying the antinociceptive effects of cho-line were discussed. RESULTS: With the administration of choline 90-120 μg per mouse, antinociceptive effects showed in a dose-dependent manner. MLA(50 μg per mouse), a-BTX(2 μg per mouse) and atropine(0.1 μg per mouse) significantly blocked the effect of choline; mecamylamine(5 μg per mouse) and naloxone(2 μg per mouse) failed to block choline-induced antinociception. CONCLUTION: Choline-induced antinociception is me-diated by α₇-nAchR subtype, while mAchR seems to be related to choline-induced antinociception.

Key words: nAchR agonist, choline, α₇-nAchR subtype, antinociceptive effect, hot-plate

中图分类号:

R965

苏冬梅, 刘跃, 王越, 王汝欢, 汪海. 胆碱对小鼠中枢镇痛效应的特征[J]. 中国临床药理学与治疗学, 2004, 9(11): 1217-1220.

SU Dong-Mei, LIU Yue, WANG Yue, WANG Ru-Huan, WANG Hai. Characteristics of antinociceptive effects of choline in central nervous system in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(11): 1217-1220.

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