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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (11): 1285-1288.

• 研究原著 • 上一篇    下一篇

泰脂安对大鼠血脂影响的实验研究

邬楠, 张金树1, 张跃飞2, 毛一卿, 李清漪, 阮元, 林虎1, 高德禄1, 谭焕然   

  1. 北京大学医学部基础医学院药理学系,北京 100083;
    1解放军305医院全军老年病研究中心,北京 100035;
    2深圳三九企业集团医药研究院,深圳 518029,广东
  • 收稿日期:2004-09-16 出版日期:2004-11-26 发布日期:2020-11-19
  • 通讯作者: 谭焕然,女,教授,研究方向:分子药理学。Tel: 010-82802004 E-mail: tardab@sun.bjmu,edu,cn
  • 作者简介:邬楠,女,硕士研究生。
  • 基金资助:
    三九企业药物研究基金的资助

Therapeutic effects of Taizhi'an capsules on hyperlipidemia in rats

WU Nan, ZHANG Qing-Shu1, ZHANG Yue-Fei2, MAO Yi-Qing, LI Qing-Yi, RUAN Yuan, LING Hu1, GAO De-Lul, TAN Huan-Ran   

  1. Departmant of Pharmacology, Medical College, Peking University, Beijing J00083, China;
    1Research Center of Gerontism Disease, PLA 305 Hospital, Beijing 100035, China;
    2Research Institute of Medicine, Shenzhen Sanjiu Enterprise Conglomerate, Shenzhen 518029, Guangdong, China
  • Received:2004-09-16 Online:2004-11-26 Published:2020-11-19

摘要: 目的: 观察泰脂安对高脂模型大鼠的降脂作用,探讨泰脂安可能的降脂作用机制。方法: 应用SD和SHR大鼠建立高脂血症模型,观察中药泰脂安对高脂大鼠的降脂作用。结果: 口服泰脂安对正常饮食的SD大鼠的血清中血脂没有影响。口服泰脂安2周可以使食用高脂饮食的大鼠血清中的胆固醇的含量明显降低,还可以提高SD大鼠血清中的脂蛋白脂肪酶含量。结论: 泰脂安对高脂模型大鼠有较好的降脂作用,其降脂作用机制可能与泰脂安升高血清中的脂蛋白脂肪酶含量有关。

关键词: 泰脂安, 高脂模型, 脂蛋白脂肪酶, 高脂血症, 中医药

Abstract: AIM: To observe the effects of Taizhi5 an capsules on reducing the hyperlipidemia in rat models, and to explore the mechanisms and the side-effects of Taizhi'an. METHODS: Hyperlipidemia animal models were set up by normal diet and high cholesterol diet in rats. The concentrations of serum lipid were detected by full automatic biochemical instrument. RESULTS: Taizhi'an obviously reduced the concentration of serum total cholesterol, triglycerides (TG) and increased the contents of LPL. Taizhi'an had no obviously influence on the concentration of glutamic oxaloacetic transaminase (GOT). CONCLUSION: Taizhi'an capsule can de-crease the hyperlipidemia. Its mechanism is related to the regulation of lipid metabolism and improvement of the concentration of LPL (lipoprotein lipase).

Key words: Taizhi'an capsule, hyperlipidemia model, LPL, hyperlipidemia, traditional Chinese medicine

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