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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (12): 1388-1392.

• 研究原著 • 上一篇    下一篇

种植肿瘤细胞数对小鼠皮下移植瘤生长及抗癌药疗效的影响

张宝来, 臧凯宏, 高王非, 李文广, 高明堂, 吴勇杰   

  1. 兰州大学药学院, 甘肃省中药新药临床前研究重点实验室, 兰州 730000, 甘肃
  • 收稿日期:2004-10-29 修回日期:2004-12-11 出版日期:2004-12-26 发布日期:2020-11-19
  • 通讯作者: 李文广, 男, 教授, 硕士生导师, 研究方向:肿瘤药理学和生物技术药品临床前研究。Tel:0931-3668356
  • 作者简介:张宝来, 男, 硕士研究生, 医师, 研究方向:肿瘤药理学和生物技术药品临床前研究。Tel:13893111684 E-mail:john_Chinese@sohu.com

Effects of different number of tumor cells on xenograft tumor growth and efficacy of anti-tumor agents in mice

ZHANG Bao-Lai, ZANG Kai-Hong, GAO Bei, LI Wen-Guang, GAO Ming-Tang, WU Yong-Jie   

  1. School of Pharmacy, Lanzhou University, Lanzhou Medical College, Gansu ProvinceKey Laboratory of Preclinical Study for New Traditional Chinese Medicine, Lanzhou 730000, Gusan, China
  • Received:2004-10-29 Revised:2004-12-11 Online:2004-12-26 Published:2020-11-19

摘要: 目的: 研究种植肿瘤细胞数对小鼠皮下移植瘤生长及抗癌药疗效的影响。方法: 小鼠右前腋窝皮下种植不同数目的小鼠肉瘤S180 细胞、小鼠肝癌H22细胞和小鼠Lewis 肺癌细胞, 观察肿瘤的生长情况, 并观察常用抗癌药阿霉素、卡铂、环磷酰胺和5-氟尿嘧啶在种植不同肿瘤细胞数时作用强度。结果: 种植肿瘤细胞数越多, 肿瘤生长越快, 出瘤时间越早, 抗癌药抑瘤率越低。结论: 种植肿瘤细胞数直接影响小鼠皮下移植瘤的生长速度, 也影响对抗癌药疗效的评价。抗癌药抑瘤率受种植肿瘤细胞数的影响, 在进行抗癌药活性评价时, 应加注意。

关键词: 肿瘤负荷, 小鼠, 肿瘤, 生长, 抗癌药

Abstract: AIM: To study the effects of different number of tumor cells on xenograft tumor growth and efficacy of anti-tumor agents inmice.METHODS: Different numbers of tumor cells were injected subcutaneously at the right armpit of the mice.The tumor volume and weight were determined.The efficacies of four anti-tumor agents were evaluated.RESULTS: The more the number of tumor cells implanted, the faster the xenograft tumor growth.The earlier the tumor emerged, the lower the inhibitory rate of antitumor agents showed.CONCLUSION: The number of tumor cells implanted obviously affects the growth of xenograft tumor in mice and lead to misevaluate in efficacy of anti-tumor agents.So the attention should be paid when the efficacies of different antitumor agents are evaluated.

Key words: tumor load, mouse, tumor growth, antitumor agents, evaluation

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