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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (2): 201-203.

• 研究原著 • 上一篇    下一篇

2-羧甲氧基苯甲醛苯甲酰腙及其配合物抑菌活性的构效关系

马兴铭, 雒艳萍, 麻宝成1, 杨汝栋1   

  1. 兰州医学院基础医学院免疫学教研室, 兰州 730000, 甘肃
  • 收稿日期:2003-07-11 修回日期:2003-08-14 出版日期:2004-02-26 发布日期:2020-11-16
  • 通讯作者: 马兴铭,男, 医学硕士, 副教授, 研究方向:中药免疫调控机理和抗菌药物合成与筛选。Tel:09313968050 E-mail: mingxm@163.com

Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone or their complexes

MA Xing-Ming, LUO Yan-Ping, MA Bao-Cheng, YANG Ru-Dong   

  1. Department of Immunology, Lanzhou Medical College, Lanzhou 730000, Gansu, China
  • Received:2003-07-11 Revised:2003-08-14 Online:2004-02-26 Published:2020-11-16

摘要: 目的: 研究2-羧甲氧基苯甲醛苯甲酰腙及其配合物的抑菌活性。方法: 合成配体2-羧甲氧基苯甲醛苯甲酰腙及其配合物, 采用K-B 法检测其对金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长抑制作用。结果: 配体2-羧甲氧基苯甲醛苯甲酰腙仅抑制金黄色葡萄球菌的生长, 其配合物能抑制金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长,形成抑菌环, 尤其Cu 配合物形成抑菌环直径最大。结论: 2-羧甲氧基苯甲醛苯甲酰腙与金属、稀土形成的配合物均有一定的抑菌作用,Cu配合物抑菌活性最强。

关键词: 腙类化合物, 配体, 配合物, 体外抑菌, K-B法

Abstract: AIM: To study bacteriostasis activities of ligand (2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone (H2L)) and their complexes.METHODS: Ligand H2L and their complexes were synthesized.The bacteriostasis activities of H2L and their complexes in vitro were tested with K-B method.RESULTS: 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone only showed bacteriostasis activities on Staphyloccus aureus and their complexes had dramatic bacteriostasis activity on Staphylococcus aureus, Escherichia coli, and Bacillus subtilis.Bacteriostasis ring diameter of Cu-complex was largest.CONCLUSION: Ligand H2L complexes have bacteriostasis activities in vitro.Bacteriostasis activities of Cu-complex are strongest among the complexes.

Key words: hydrazones compounds, ligand, complexes, bacteriostasis, Kirby-Bauer method

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