老智灵口服液用于血管性痴呆临床疗效的评价

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (2): 204-207.

老智灵口服液用于血管性痴呆临床疗效的评价

高唱, 王景周

第三军医大学大坪医院野战外科研究所神经内科, 重庆 400042

收稿日期:2003-08-21 修回日期:2003-08-21 出版日期:2004-02-26 发布日期:2020-11-16
通讯作者: 高唱,男, 医学博士, 主治医师, 主要从事脑血管病研究。Tel:020-33358589 　E-mail: gaochang888@yahoo.com.cn
基金资助:
重庆市科委科研基金资助项目(NO.5657)

Evaluation of clinical effect of laozhiling oral liquid on vascular dementia

GAO Chang, WANG Jing-Zhou

Department of Neurology, Daping Hospital of the Third Military Medical University, Chongqing 400042, China

Received:2003-08-21 Revised:2003-08-21 Online:2004-02-26 Published:2020-11-16

摘要/Abstract

摘要： 目的: 探讨老智灵口服液治疗血管性痴呆(VD) 的临床疗效。方法: 采用老智灵口服液治疗血管性痴呆患者39 例, 并用金纳多针剂(32 例, 静脉滴注) 作对照, 观察治疗前后简易精神状态量表(MMSE) 、长谷川痴呆量表(HDS) 、日常生活活动量表(ADL), 事件相关电位P300, 脑脊液AngII 和AVP含量的变化。结果: 老智灵组总有效率为61.54 %,对照组总有效率为59.38 %, 两组比较无统计学意义(P >0.05) 。两组治疗后MMSE 、HDS 积分和AVP含量均较治疗前显著增加(P<0.01), 而ADL 评分和AngII 含量显著降低(P<0.01) 。结论: 老智灵口服液治疗VD 有效, 其机理与调节神经肽功能有关。

关键词: 老智灵口服液, 血管性痴呆, 认知功能, 血管紧张素II, 精氨酸加压素

Abstract: AIM: To study the effect of laozhiling oral liquid (LZL) in treating vascular dementia.METHODS: Patients were randomly divided into two groups:39 patients in the LZL treated group and 32 patients in the control group treated by Jinnaduo injection with therapeutic course of 3 months.Changes of minimental state examination (MMSE), Hasegawa' s Dementia Scale (HDS),activity of daily living (ADL) scores and levels of Angiotensin Ⅱ(AngII), Arginine vesopresin (AVP) and P300PL in cerebrospinal fluid were observed.RESULTS: The total effective rates in the LZL and Jinnaduo group were 61.54 % and 59.38 %, respectively, which had no significant difference between the two groups(P >0.05). MMSE, HDS scores of patients and the concentration of AVP could be obviously elevated (P<0.01), but the scores of ADL and levels of AngII markedly decreased (P<0.01).CONCLUSION: LZL has definite effect in treating VD and its therapeutic mechanism may be related to the actions of improving the function of neuropeptides.

Key words: laozhiling oral liquid (LZL), vascular dementia, cognition function, angiotensin II, arginine vasopresin

中图分类号:

R969.4

高唱, 王景周. 老智灵口服液用于血管性痴呆临床疗效的评价[J]. 中国临床药理学与治疗学, 2004, 9(2): 204-207.

GAO Chang, WANG Jing-Zhou. Evaluation of clinical effect of laozhiling oral liquid on vascular dementia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(2): 204-207.

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