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中国临床药理学与治疗学 ›› 2022, Vol. 27 ›› Issue (12): 1365-1374.doi: 10.12092/j.issn.1009-2501.2022.12.006

• 麻醉药与脑功能障碍专刊 • 上一篇    下一篇

麻醉及镇痛药物与认知功能

倪渊博1,张昕1,李仪1,刘存明2   

  1. 1南京医科大学,南京 210000,江苏;2南京医科大学第一附属医院麻醉与围术期医学科,南京 210000,江苏

  • 收稿日期:2022-09-05 修回日期:2022-11-30 出版日期:2022-12-26 发布日期:2023-01-13
  • 通讯作者: 刘存明,男,博士,主任医师,博士生导师,研究方向:麻醉与认知。 E-mail: cunmingliu@njmu.edu.cn
  • 作者简介:倪渊博,男,硕士在读,研究方向:麻醉学。 E-mail: nyb2837468944@163.com
  • 基金资助:
    江苏省自然科学基金面上项目(BK20211382)

Anesthetics, analgesics and cognitive function

NI Yuanbo1, ZHANG Xin1, LI Yi1, LIU Cunming2   

  1. 1Nanjing Medical University, Nanjing 210000, Jiangsu, China; 2Department of Anesthesiology and Perioperative Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu, China
  • Received:2022-09-05 Revised:2022-11-30 Online:2022-12-26 Published:2023-01-13

摘要: 认知功能损害已成为影响老年患者生活质量的重要因素。现有的研究尚不能回答是何种因素引起认知功能减退,不少学者认为麻醉与镇痛药物可能在认知功能障碍中扮演重要角色。本综述将探讨不同麻醉镇痛药对认知功能的影响并简要叙述其机制,为临床合理选择用药方案提供参考。

关键词: 认知功能障碍, 全身麻醉, 静脉麻醉药, 阿片类药物, 吸入麻醉药

Abstract:

Cognitive dysfunction has become a pivotal factor affecting the quality of life of elderly patients. The existing literatures can not explain the factors causing cognitive decline. Many researchers believe that anesthetics and analgesics may play important roles in cognitive dysfunction. This review will discuss the effects of different anesthetics and analgesics on cognitive function and briefly describe their mechanisms, so as to provide reference for the rational choice of medications in clinical practice.

Key words: cognitive dysfunction, general anesthesia, intravenous anesthetics, opioids, inhaled anesthetics

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