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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (3): 289-293.

• 研究原著 • 上一篇    下一篇

苦杏仁苷对佐剂性炎症影响的实验研究

方伟蓉1, 李运曼, 钟林霖   

  1. 中国药科大学生理学教研室, 1药理系, 南京210009, 江苏
  • 收稿日期:2003-11-19 修回日期:2004-01-09 出版日期:2004-03-26 发布日期:2020-11-21
  • 通讯作者: 李运曼, 女, 博士生, 硕士生导师, 研究方向:肿瘤多药耐药逆转及心血管药理。Tel:025-83271185  E-mail:yucaoren@sina.com 。
  • 作者简介:方伟蓉, 女, 硕士研究生。E-mail:fwrr@sina.com

Experimental study of effects of amygdalin on adjuvant inflammatory

FANG Wei-Rong1, LI Yun-Man, ZHONG Lin-Lin   

  1. Department of Physiology, 1Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2003-11-19 Revised:2004-01-09 Online:2004-03-26 Published:2020-11-21

摘要: 目的:观察苦杏仁苷对大鼠佐剂性炎症(机体异常免疫)和小鼠碳粒廓清(机体正常免疫)的影响,以揭示其免疫调节作用。方法:采用皮下注射Freund's 完全佐剂抗原, 形成大鼠慢性免疫萎缩性胃炎模型, 测定胃液游离酸度、总酸度及胃蛋白酶活性;大鼠足跖皮内注射Freund's 完全佐剂形成佐剂性关节炎, 测定佐剂性关节炎原发病变的足跖肿胀度、继发病变的肿胀率及炎症抑制率;小鼠碳粒廓清实验测定廓清指数(K)及吞噬指数(α)。结果:苦杏仁苷高剂量组可极显著降低大鼠胃蛋白酶活性, 抑制佐剂性关节炎原发病变的足跖肿胀度, 减轻继发病变的肿胀率, 提高小鼠的廓清指数和吞噬指数(P <0.01);苦杏仁苷中剂量组可显著降低大鼠胃蛋白酶活性, 提高小鼠廓清指数(P <0.05), 极显著降低佐剂性关节炎原发和继发病变的肿胀度、肿胀率(P <0.01);各剂量组的苦杏仁苷对大鼠胃液酸度无明显影响作用(P >0.05)。结论:苦杏仁苷能抑制佐剂性炎症, 增强巨噬细胞的吞噬功能, 具有调节免疫功能的作用。

关键词: 苦杏仁苷, 免疫佐剂, 萎缩性胃炎, 佐剂性关节炎, 碳粒廓清

Abstract: AIM: To observe the effects of amygdalin in immunoloregulation.METHODS: Subcutaneous injection of Freund adjuvant resulted in atrophic gastritis models in rats, and then the free and total acidity and activity of pepsin in gastric juice were determined after ig amygdalin for 6 months.Intradermal injection of Freund adjuvant caused adjuvant arthrositis in rats after ig amygdalin for 7 d, and then inflammatory swelling of primary inflammatory and swelling percentage (%)and inhibition percentage (%) of recurrent inflammatory were determined as well as the indexes of clearance (K)and phagocytosis (α)by the carbon granular clearance in mice after ig amygdalin for 7 d.RESULTS: The activity of pepsin in high dose group and middle dose group decreased (P <0.05).The acidity of gastric juice of all groups had no significant difference (P >0.05).Amygdalin could prevent adjuvant arthrositis in rats, and high andmiddle dose of amygdalins could inhibit inflammatory swelling (P < 0.01).K and αincreased (P <0.01)in high dose group, but K increased in middle dose group (P < 0.05).CONCLUSION: Amygdalin can regulate immunological function in animal models.

Key words: amygdalin, atrophic gastritis, adjuvant arthrositis, carbon granular clearance

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