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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (3): 333-336.

• 研究原著 • 上一篇    下一篇

生长抑素及类似物对大肠癌组织血管生成的调控

武健, 李先海, 夏祥厚, 王亚兵, 阎竟一   

  1. 皖南医学院附属弋矶山医院普外科五病区, 芜湖241001, 安徽
  • 收稿日期:2003-09-02 修回日期:2003-11-24 出版日期:2004-03-26 发布日期:2020-11-21
  • 通讯作者: 武健, 男, 副主任医师, 副教授, 主要研究神经内分泌与胃肠癌的关系。Tel:0553-5738856-2305  E-mail:lxhoop1010@sina.com

Antiangiogenic effects of somatostatin and its analogues in rectal cancer

WU Jian, LI Xian-Hai, XIA Xiang-Hou, WANG Ya-Bin, YAN Jing-Yi   

  1. Department of General Surgery, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2003-09-02 Revised:2003-11-24 Online:2004-03-26 Published:2020-11-21

摘要: 目的:研究生长抑素(somatostatin, SS) 与大肠癌组织微血管密度(MVD) 及相关因子血管内皮细胞生长因子(VEGF) 和基质金属蛋白酶抑制剂-2(TIMP-2) 表达的相关性。方法:应用免疫组织化学S-P 法, 分析80 例手术切除的新鲜大肠癌标本SS,CD34,VEGF, TIMP-2 的变化。结果:大肠癌组织中SS 表达阳性率为66.25 %, SS 高表达组的大肠癌MVD 的表达显著低于SS 低表达组(P <0.01), SS 表达与TIMP-2 表达呈明显正相关(P <0.05), 与VEGF呈显著负相关(P <0.05) 。结论:SS 及VEGF, TIMP-2 在人体大肠癌组织中的表达有一定拮抗性。SS 的抑癌机制之一可能是干扰了血管生长因子的合成,影响了细胞内调节细胞生长信号的传递, 从而抑制肿瘤血管的生长。

关键词: 大肠癌, 生长抑素, 血管内皮细胞生长因子, 基质金属蛋白酶抑制剂-2

Abstract: AIM: To investigate the correlation between the somatostatin analogues (SS) and angiogenesis in colorectal carcinoma.METHODS: 80 cases of colorectal carcinomas were examined by immunohistochemical staining (S-P method) using anti-SS, anti-VEGF and anti-CD34 (+) monoclonal antibodies.RESULTS: SS positive staining was obtained in 53 out of 80 cases (66.25 %), and mainly in the cytoplasm of tumor cells. Microvessel density (MVD) expression was more intense in the negative group in comparison with others (P < 0.01).A significant correlation was found between the SS, VEGF and TIMP-2.The expression of VEGF in the SS positive group was lower than that in the negative group (P <0.05), while that of TIMP-2 reversed (P < 0.05).CONCLUSION: There is certain antagonism between the expression of SS, VEGF and TIMP-2 in human colon cancer.One of the mechanisms of tumor inhibition by SS may be the interference with the synthesis of growth factors by tumor cells and with transmission of intracellular signals that regulates cell growth.

Key words: colorectal carcinoma, somatostatin, growth factors, rectal cancer

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