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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (4): 386-388.

• 研究原著 • 上一篇    下一篇

蛹虫草提取物对内毒素引起小鼠急性肺损伤的保护作用

戴瑛, 张斌, 周勇, 程新锐, 杜冠华   

  1. 中国医学科学院中国协和医科大学药物研究所, 北京100050
  • 收稿日期:2003-11-24 修回日期:2004-01-07 出版日期:2004-04-26 发布日期:2020-11-20
  • 通讯作者: 杜冠华, 男, 研究员, 博士生导师, 研究方向:药物发现和心血管药理研究。Tel:010-63165184 E-mail:dugh@imm.ac.cn
  • 作者简介:戴瑛, 女, 硕士研究生, 研究方向:心血管药物研究。
  • 基金资助:
    863 计划创新药物和中药现代化重大专项(№2002AA2Z343B);国家高技术研究发展计划(863 计划) 项目(№2003AA2082033)

Protective effect of Cordyceps sinensis extract on acute lung injury induced by lipopolysaccharide in mice

DAI Ying, ZHANG Bin, ZHOU Yong, CHENG Xin-Rui, DU Guan-Hua   

  1. Institute of Materia Matical, PUMC, Beijing 100050, China
  • Received:2003-11-24 Revised:2004-01-07 Online:2004-04-26 Published:2020-11-20

摘要: 目的:观察蛹虫草提取物对内毒素引起小鼠急性肺损伤的保护作用。方法:建立内毒素急性损伤小鼠肺病理模型, 造模4 和8 h 后, 用蛹虫草提取物治疗, 造模24 h 后, 对血细胞和肺灌洗液中细胞进行计数并测定肺灌洗液中蛋白酶的活性和蛋白的含量。结果:蛹虫草提取物对血液成分没有明显影响, 但可以使肺灌洗液中白细胞、粒细胞的含量有所降低, 而淋巴细胞和单核细胞的数量有所增加, 蛋白酶活性降低。结论:蛹虫草提取物可调节机体组织的免疫功能, 可以缓解由于内毒素或类似物质造成的肺部炎症, 具有一定的肺保护作用。

关键词: 蛹虫草, 内毒素, 急性肺损伤, 肺灌洗, 肺保护作用

Abstract: AIM: To study the effects of Cordyceps sinensis extract on experimental acute lung injury model in mice.METHODS: Acute lung injury model was induced by intratracheal instillating lipopolysaccharide (LPS, 2.4 mg·kg-1) in mice.The mice were given Cordyceps sinensis extract (ig, 10, 30 mg·kg-1) in 4 and 8 h after receiving LPS.The cell counts in the blood and bronchoalveolar lavage (BAL), the protease activity and the protein concentration in BAL were measured.RESULTS: Cordyceps sinensis extract could decrease the number of leukocyte and neutrophil, and increase the counts of lymphocyte and monocyte.The activity of protease was significantly depressed by the preparation. CONCLUSION: Cordyceps sinensis extract shows protective effect on the acute injured lung in mice.

Key words: Cordyceps sinensis, lipopolysaccharide(LPS), bronchoalveolar lavage, acute lung injury, protective effect

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