补肾活血法治疗慢性再生障碍性贫血疗效的临床评价

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (4): 423-425.

补肾活血法治疗慢性再生障碍性贫血疗效的临床评价

张晓慧, 梁凤珍¹

长春中医学院附属医院国家药品临床研究基地, ¹ICU, 长春130021, 吉林

收稿日期:2004-03-22 修回日期:2004-04-20 出版日期:2004-04-26 发布日期:2020-11-20
通讯作者: 张晓慧, 女, 副教授, 副主任医师, 研究方向:主要从事中医内科学临床研究。Tel:0431-6177016 E-mail:zhangxiaohui01abc@yahoo.cm.cn

Clinical evaluation of the effect of therapy of kidney tonification and blood activation on patients with chronic aplastic anemia

ZHANG Xiao-Hui, LIANG Feng-Zhen¹

National Base of Drug Clinical Trial, ¹ICU, Affiliated Hospital of Changchun Traditional Chinese Medicine College,Changchun 130021, Jilin, China

Received:2004-03-22 Revised:2004-04-20 Online:2004-04-26 Published:2020-11-20

摘要/Abstract

摘要： 目的:评价补肾活血法对慢性再生障碍性贫血(chronic aplastic anemia, CAA) 有效性和安全性。方法:CAA 患者60 例随机分为治疗组和对照组, 治疗组给予补肾活血中药, 对照组给予再障生血片, 采用原位杂交法检测治疗前后骨髓造血细胞IL-2、IL-8水平的变化, 并与正常组18 例相比较。结果:治疗组疗效高于对照组, 基本治愈率分别为66.67 %和40.00 %(P <0.05) 。治疗前CAA 患者骨髓造血细胞IL-2、IL-8 阳性指数均高于正常对照组(P <0.05);各组疗后IL-2、IL-8 阳性指数明显降低(P <0.05);治疗后治疗组IL-2、IL-8 阳性指数高于对照组(P <0.05) 。结论:补肾活血中药能够降低CAA病人骨髓造血细胞IL-2、IL-8 分泌水平, 促进骨髓造血功能恢复。

关键词: 补肾活血法, 再生障碍性贫血, 造血细胞, IL-2, IL-8, 原位杂交法

Abstract: AIM: To evaluate the effect of therapy of “kidney tonification and blood activation” on patients with chronic aplastic anemia (CAA).METHODS: 60 CAA patients were randomly assigned to treatment group and control group, with the former given traditional Chinese medicine for tonifying kidney and activating blood and the latter given CAA hematogenetic tablets.The levels of IL-2 and IL-8 were compared with those before and after the treatments and another 18 cases as normal group.RESULTS: Patients from treatment group and control group were cured with remission rate 66.67 % and 40.00 %, respectively.Treatment group was superior to control group in effectiveness(P <0.05).The positive indexes of IL-2 and IL-8 before treatment were both higher than those of normal group (P <0.05), while after treatment they decreased (P <0.05).CONCLUSION: The therapy for tonifying kidney and activating blood can reduce the secretion of IL-2 and IL-8 in CAA patients, and promote the restoration of hematogenetic function.

Key words: kidney tonification and blood activation, chronic aplastic anemia, CAA hematogenetic cells, IL-2, IL-8, hybridigation in situ

中图分类号:

R973

张晓慧, 梁凤珍. 补肾活血法治疗慢性再生障碍性贫血疗效的临床评价[J]. 中国临床药理学与治疗学, 2004, 9(4): 423-425.

ZHANG Xiao-Hui, LIANG Feng-Zhen. Clinical evaluation of the effect of therapy of kidney tonification and blood activation on patients with chronic aplastic anemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(4): 423-425.

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