大鼠口服尼莫地平吸收动力学性别差异研究

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (5): 532-535.

大鼠口服尼莫地平吸收动力学性别差异研究

王晓莉, 谢林, 刘晓东

中国药科大学药物代谢动力学重点实验室, 南京210009, 江苏

收稿日期:2004-02-17 修回日期:2004-02-17 发布日期:2020-11-22
通讯作者: 刘晓东, 男, 博士, 主任, 博士生导师, 研究方向:药物代谢动力学。Tel:025-83271006 　E-mai l:xdliu1960@hotmai l.com
作者简介:王晓莉, 女, 在读硕士。
基金资助:
国家863 计划项目(No:2003AA2Z347A);江苏省药物代谢动力学重点实验室项目(No:BM2001201)

Gender difference of nimodipine pharmacokinetics in rats

WANG Xiao-Li, XIE Lin, LIU Xiao-Dong

Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2004-02-17 Revised:2004-02-17 Published:2020-11-22

摘要/Abstract

摘要： 目的研究大鼠ig 尼莫地平(NMD) 后体内药物动力学是否存在性别差异, 并考察合用红霉素(Ery) 后血浆中NMD 变化。方法雌性和雄性大鼠单独ig NMD 或与Ery 合用后, 用HPLC 法测定血浆中NMD 的浓度。结果大鼠ig 给药NMD(20 mg·kg^-1), 雌鼠血浆中的NMD 浓度显著高于雄鼠(P <0.05), 其AUC 值是雄鼠的4.4 倍。合用Ery后, 与单用比较, 无论是雄鼠, 还是雌鼠, 血浆中NMD 浓度显著升高, AUC 值分别提高了2.0 和1.6倍。合用Ery, NMD 的性别差异仍然存在。雌鼠的浓度仍然高于雄鼠, AUC 值是雄鼠的3.4 倍。结论 NMD 在大鼠体内口服吸收动力学存在性别差异, 并且红霉素可以提高NMD 在血浆中的浓度。

关键词: 尼莫地平, 性别差异, 红霉素, 吸收动力学, 药物相互作用

Abstract: AIM: To study gender difference in nimodipine (NMD) pharmacokinetics in rats after oral administration NMD and co-administration erythromycin (Ery). METHODS: NMD concentrations in plasma were determined by HPLC after ig administration of 20 mg·kg^-1 NMD and co-administration of 50 mg·kg^-1 Ery, respectively. RESULTS: Marked gender differences for NMD concentrations in rat plasma were found after oral administration of 20 mg·kg^-1 NMD.In groups of NMD alone, the plasma concentrations of NMD in male rats were significantly (P <0.05) lower than those in female rats.AUC value of NMD in male rats was only about one-fourth of that in female rats.In groups for co-administration of Ery, there also exists gender difference;the concentrations of NMD in male rats also were significantly (P <0.05) lower than those in female rats and AUC value of NMD in female rats was about 3.4-folds of that in male rats.In addition, NMD concentration in plasma was significantly increased after co-administration Ery, which AUC values increased 2.0-and 1.6-folds of those in alone NMD, respectively. CONCLUSION: There are marked gender differences in NMD pharmacokinetics of oral administration in rats, and Ery can increase plasma concentrations of NMD.

Key words: nimidipine, gender difference, erythromycin, pharmacokinetics, drug interaction

中图分类号:

R969.1

王晓莉, 谢林, 刘晓东. 大鼠口服尼莫地平吸收动力学性别差异研究[J]. 中国临床药理学与治疗学, 2004, 9(5): 532-535.

WANG Xiao-Li, XIE Lin, LIU Xiao-Dong. Gender difference of nimodipine pharmacokinetics in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(5): 532-535.

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