头孢硫脒与其他6种抗菌药物对表皮葡萄球菌体外联合药敏的研究

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (5): 536-539.

头孢硫脒与其他6种抗菌药物对表皮葡萄球菌体外联合药敏的研究

周筱青, 裴斐, 柴栋, 方翼, 王睿

解放军总医院药材处, 北京100853

收稿日期:2003-11-19 修回日期:2004-01-08 发布日期:2020-11-22
通讯作者: 裴斐, 男, 硕士, 研究方向:抗生素耐药性。Tel:010-66937909 E-mai l:pei_fei_@sohu.com
作者简介:周筱青, 女, 主任药师, 研究方向:医院药学。Tel:010-66939550

Antibacterial activity of cefathiamidine in vitro combined with 6 antimicrobial agents against Staphylococcus epidermidis

ZHOU Xiao-Qing, PEI Fei, CHAI Dong, FANG Yi, WANG Rui

The Chinese PLAGeneral Hospital, Beijing 100853, China

Received:2003-11-19 Revised:2004-01-08 Published:2020-11-22

摘要/Abstract

摘要： 目的评价头孢硫脒分别与万古霉素、奈替米星、阿米卡星、环丙沙星、左氧沙星和加替沙星等6种抗菌药物联合用药, 对于表皮葡萄球菌(Staphylococcusepidermidis, SE) 的体外联合抗菌效应。方法采用棋盘法设计, 微量肉汤稀释法测定不同浓度组合的6 组抗菌药物对30 株临床分离的表皮葡萄球菌的最低抑菌浓度(MIC), 并计算部分抑菌指数(FIC指数)。结果头孢硫脒对表皮葡萄球菌的MIC₅₀、MIC90为1、64 mg·L^-1;与万古霉素、奈替米星、阿米卡星、环丙沙星、左氧沙星、加替沙星联合应用后, 其MIC₅₀分别降低至0.125、0.125、0.125、0.125、0.25、0.125 mg·L^-1, MIC₉₀ 分别降低至1、1、1、2、1、1 mg·L^-1。结论 6 种抗菌药物与头孢硫脒联合用药后, 对表皮葡萄球菌球菌基本表现为协同或相加作用, 并以协同作用为主, 无关作用较少, 无拮抗作用。

关键词: 头孢硫脒, 表皮葡萄球菌, 联合药敏, 棋盘法

Abstract: AIM: To evaluate the antibiotic effects in vitro of cefathiamidine combined with 6 antimicrobial agents against Staphylococcus epidermidis. METHODS: The protocol was designed by checkerboard method, the MICs against 30 strains of Staphylococcus epidermidis were determined by broth dilution method, and the FIC index was calculated according to MIC values. RESULTS: The MIC50 of cefathiamidine alone against Staphylococcus aureus was 16 mg·L^-1 and theMIC50 of cefathiamidine combined with 6 antimicrobial agents was reduced to 0.125, 0.125, 0.125, 0.125, 0.25, 0.125 mg·L^-1, respectively.The MIC90 of cefathiamidine alone against Staphylococcus epidermidis was reduced to 1, 1, 1, 2, 1 mg·L^-1, respectively. CONCLUSION: The synergism and additivity are shown when cefathiamidine combined with 6 antimicrobial agents against 30 strains Staphylococcus epidermidis, and the autonomy and antagonism are not found.

Key words: cefathiamidine, Staphylococcus epidermidis, FIC, checkerboard method

中图分类号:

周筱青, 裴斐, 柴栋, 方翼, 王睿. 头孢硫脒与其他6种抗菌药物对表皮葡萄球菌体外联合药敏的研究[J]. 中国临床药理学与治疗学, 2004, 9(5): 536-539.

ZHOU Xiao-Qing, PEI Fei, CHAI Dong, FANG Yi, WANG Rui. Antibacterial activity of cefathiamidine in vitro combined with 6 antimicrobial agents against Staphylococcus epidermidis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(5): 536-539.

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