心血管疾病中血管平滑肌细胞增殖与药物开发

摘要/Abstract

摘要： 血管平滑肌细胞增殖在高血压、动脉粥样硬化、再狭窄等心血管疾病的发生、发展中起着重要的作用。本文对血管平滑肌细胞胞外调控因素、胞内信号传导、细胞周期的研究现状及基于此三方面的药物研发进行综述。

Abstract: The proliferation of vascular smooth muscle cells plays an important role in the initiation and aggravation in cardiovascular diseases such as hypertension, arteriosclerosis, restenosis.This article reviewed the progress in the studies on extracellular influencing factors, intracellular signal transduction, cell cycle of vascular smooth muscle cells and the relative drug research and development.

Key words: vascular smooth muscle cell, proliferation, signal transduction, cell cycle, drug research and Development

中图分类号:

R364.31

马秉亮, 吴玉林. 心血管疾病中血管平滑肌细胞增殖与药物开发[J]. 中国临床药理学与治疗学, 2004, 9(8): 845-850.

MA Bing-Liang, WU Yu-Lin. Proliferation of vascular smooth muscle cells in cardiovascular diseases and drug research and development[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(8): 845-850.

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