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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 922-924.

• 研究原著 • 上一篇    下一篇

HPLC-MS法研究碘化N-正丁基氟哌啶醇在兔体内的药代动力学

林朝仙1, 石刚刚, 罗文鸿2, 李慧2, 郑锦鸿, 高分飞   

  1. 汕头大学医学院药物研究室, 1第一附属医院, 2中心实验室, 汕头515031, 广东
  • 收稿日期:2004-05-31 修回日期:2004-07-16 出版日期:2004-08-26 发布日期:2020-11-20
  • 通讯作者: 石刚刚,男,教授,博士生导师,研究方向:心血管新药研究与开发。Tel:0754-8900301 E-mail:ggshi@stu.edu.cn
  • 作者简介:林朝仙,男,副主任药师。
  • 基金资助:
    国家自然科学基金(№30070304);广东省科技计划项目(№C30104);广东省自然科学基金重点项目资助课题(№021235)

Pharmacokinetics of N-n-butyl haloperidol iodide determined by HPLCMS method in rabbits

LIN Chao-Xian1, SHI Gang-Gang, LUO Wen-Hong, LI Hui2, ZHENG Jin-Hong, GAO Fen-Fei   

  1. Department of Pharmacology, 1The First Affiliated Hospital, 2Central Laboratory, Shantou University Medical College, Shangtou 515031, Guangdong, China
  • Received:2004-05-31 Revised:2004-07-16 Online:2004-08-26 Published:2020-11-20

摘要: 目的: 研究碘化N-正丁基氟哌啶醇(F2)在兔体内的药代动力学过程。方法: 6只新西兰兔耳缘静脉注射碘化N-正丁基氟哌啶醇(F2)2.0 mg·kg-1后采集血样,用高效液相色谱-质谱(HPLC-MS)联用技术测定血浆药物浓度,并用3p97 软件拟合计算药代动力学参数。结果和结论: 兔耳缘静脉给药后的血药浓度-时间曲线符合二室开放模型,其主要药动学参数为:分布半衰期T12α是0.10 h,消除半衰期Σ12β 是6.4 h,曲线下面积AUC 为183 μg·h-1·L-1,中央室分布容积VC 为4 L,清除率Cl 为12.9 L·h-1。HPLC-MS 联用方法测定F2 血药浓度,灵敏度高,专属性强。

关键词: 碘化N-正丁基氟哌啶醇(F2 ), 兔, 药代动力学, 高效液相-质谱(HPLC-MS) 联用技术

Abstract: AIM: To study pharmacokinetics of N-nbutyl haloperidol iodide (F2) in rabbits.METHODS: Blood samples were collected at different time points after six rabbits were given F2 2.0 mg·kg-1, iv.Then the plasma concentrations of F2 were detected by HPLC-MS method.And pharmacokinetic parameters were calculated using the 3p97 program.RESULTS AND CONCLUSION: The open two-compartment model can best describe the concentration-time curve of F2.The major pharmacokinetic parameters are listed as following:the half-life of distribution phase T12α=0.10 h, the half-life of elimination phase Σ12β=6.4 h, the volume of the central compartment Vc=4 L, the total areas under the concentration-time curve AUC=183 μg·h-1·L-1, and the plasma clearance CL=12.9 L·h-1.HPLC-MS is a sensitive and specific method in this study.

Key words: N-n-butyl Haloperidol Iodide (F2 ), rabbit, pharmacokinetics, HPLC-MS

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