关键词: 阿魏酸乙酯, 血小板, 钙离子, 肝损伤, 丙二醛

Abstract: AIM: To investigate the pharmacological effects and mechanism of ethyl ferulate (EF).METHODS: The platelet congregate rate was observed by congregater TYXN-91 and the platelet intracellular calcium oscillation was observed by laser scanning.The acute liver injury model of mice was made by using the CCl4 156 mg·kg^-1, ip.Then the levels of ALT and AST were determined in serum and the levels of MDA and SOD in the liver.RESULTS: The inhibition rate of the platelet congregate were 26.3 %±3.3 %, 33.4 %±2.4 %, 73.4 %±3.1 %, and 94.9 %±2.7 %(n=8)in different concentration(0.1, 0.5, 1.5, and 3.0 mmol·L^-1)of ethyl ferulate, respectively.It was higher than those in the same concentrations of ferulic acid.The change of the fluctuation of calcium (ΔFI 4.6 ±1.7)in EF group was much lower than the rest level (10.3 ±2.6)(n=8, P <0.01).The levels of AST and ALT in serum andMDA in the liver tissue of EF group were obviously lower than those of the control group.It also showed that EF could significantly enhance the activities of SOD.CONCLUSION: The inhibition of ethyl ferulate on platelet congregation induced by ADP is much better than that of ferulic acid.Ethyl ferulate against the CCl4 acute liver injury is better than that of ferulic acid in mice.

Key words: ethyl ferulate, blood platelets, calcium ion, acute liver injury, MDA