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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 1019-1022.

• 研究原著 • 上一篇    下一篇

人参须对四氯化碳致小鼠肝纤维化的保护作用

冯有辉, 何康, 邹丽宜1,许碧连1, 刘钰瑜1   

  1. 广东医学院生理科学实验室, 1药理教研室, 湛江524023, 广东
  • 收稿日期:2004-06-23 修回日期:2004-08-10 出版日期:2004-09-26 发布日期:2020-11-23
  • 通讯作者: 冯有辉, 男, 本科, 实验师, 研究方向:实验动物学。Tel:0759-2388424 E-mail:slkxfyh @xinhuanet.com

Preventive effects of Ginseng fiber on hepatic fibrosis induced by CCl4 in mice

FENG You-Hui, HE Kang, ZOU Li-Yi1, XU Bi-Lian1, LIU Yu-Yu1   

  1. Laboratory of Physiological Science, 1Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, China
  • Received:2004-06-23 Revised:2004-08-10 Online:2004-09-26 Published:2020-11-23

摘要: 目的: 观察人参须对四氯化碳致小鼠肝纤维化的影响。方法: 运用皮下多次注射四氯化碳(CCl4)致小鼠慢性肝损伤模型, 观察人参须对小鼠肝组织病理变化、血清丙氨酸氨基转移酶(ALT/GPT)、天冬氨酸氨基转移酶(AST/GOT)、总蛋白(TP)、白蛋白(Alb)和白蛋白/球蛋白(A/G)的比值以及内脏器官重量的影响。结果: 人参须能够显著降低由CCl4 引起的肝、脾重量增加及血清ALT 、TP 的升高, 明显减轻CCl4 引起的肝坏死病变, 与秋水仙碱无差别。结论: 人参须对四氯化碳致小鼠肝纤维化有保护作用。

关键词: 人参须, 肝纤维化, 秋水仙碱, 四氯化碳, 小鼠

Abstract: AIM: To study the effects of Ginseng fiber on hepatic fibrosis induced by CCl4 in mice.METHODS: Forty PCR Mice were randomly divided into 4 the control group, the NS group, the colchicine group and the Ginseng fiber groups. Rats in control group were treated by daily oral gavage with vehicle. Rats in other three groups were given SC injection of 40 %CCl4 10 ml·kg-1 and treated by either daily oral gavage with vehicle, or colchicine at 0. 1 ml·kg-1, or Ginseng fiber at 10 g·kg-1 for 42 d. The liver injury indexes were measured.RESULTS: Compared with control group, the serum enzymes of alanine aminotransferase (ALT), aspartic acid aminotransferase(AST)were markedly increased but serum albumin (Alb)and A/G were decreased distinctly in CCl4 group whose liver slides also showed typical liver cirrhosis. Ginseng fiber markedly prevented CCl4-induced increases in liverweight, serum ALT and TP. Ginseng fiber lightened the hepatic pathological necrosis resulting from CCl4. The preventive effect of Ginseng fiber was identical to that of colchicine.CONCLUSION: Ginseng fiber can prevent hepatic fibrosis induced by CCl4 in mice.

Key words: Ginseng fiber, hepatic fibrosis, colchicine, CCl4, mice

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