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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (1): 108-111.

• 研究原著 • 上一篇    下一篇

应激与去卵巢对小鼠行为活动的影响及中药复方Ⅰ的防治作用

黄贱英1, 连晓媛2, 陈奇, 毕明   

  1. 江西中医学院中药药理教研室, 南昌 330006, 江西
  • 收稿日期:2004-04-30 修回日期:2004-09-01 出版日期:2005-01-26 发布日期:2020-11-19
  • 通讯作者: 陈奇, 男, 教授, 博士生导师, 研究方向:中药复方作用及作用机制研究。Tel:0791-6825769 E-mail:chenqi606@263.net
  • 作者简介:1 黄贱英, 现为北京中医药大学博士生。2 连晓媛, 博士, 现在Baylor College of Medicine(Houston, USA)
  • 基金资助:
    江西省自然科学基金课题(No9940057)

Effects of stress and ovariectomy on behavior activity in mice and intervention of TCM complex Ⅰ

HUANG Jian-ying, LIAN Xiao-yuan, CHEN Qi, BI Ming   

  1. Department of TCM Pharmacology, Jiangxi College of TCM, Nanchang 330006, Jiangxi, China
  • Received:2004-04-30 Revised:2004-09-01 Online:2005-01-26 Published:2020-11-19

摘要: 目的: 观察应激和去卵巢造模对小鼠行为活动的影响, 并观察中药复方Ⅰ 对其的防治作用。方法: 本研究首次采用应激和去卵巢造模观察对小鼠睡眠时间、常压耐缺氧时间、爬绳时间及活动次数的影响, 观察中药复方Ⅰ对其的防治作用。结果: 单纯应激、单纯去卵巢以及应激与去卵巢对小鼠睡眠、耐常压缺氧、爬绳及活动次数有不同程度的影响, 但应激与去卵巢比单纯应激、单纯去卵巢对小鼠的影响更为强烈。应激和去卵巢可致小鼠睡眠障碍加剧,其睡眠潜伏期延长, 睡眠时间缩短;常压缺氧存活时间缩短, 爬绳时间缩短, 小鼠活动次数增加。结论: 应激能使去卵巢小鼠对外界环境改变的敏感性增强, 与目前临床更年期综合征发病机制相符。由酸枣仁、知母等药组成的中药复方Ⅰ 可改善应激与去卵巢小鼠的睡眠, 缩短小鼠入睡潜伏期, 延长小鼠睡眠时间;能增加小鼠体力, 使其耐常压缺氧存活时间延长, 爬绳时间延长;还具有一定的镇静作用, 可使小鼠活动次数减少。

关键词: 应激, 去卵巢, 行为活动, 更年期综合征

Abstract: AIM: To observe the effect of stress and ovariectomy on behavior activity in mice and the prevention and therapy of the TCM complex Ⅰ composed of spine date seed and common anemarrhena rhizome.METHODS: The effect of stress and ovariectomy were investigated on bedtime, survival time under hypoxia, climbing time on the string and number of times of the activity in mice, and the prevention and therapy of TCM the complex Ⅰwere observed.RESULTS: The effect of stress, ovariectomy, stress and ovariectomy were different on bedtime, survival time under hypoxia and climbing time on the string and the number of times of the activity in mice. The effect of stress and ovariectomy on previous parameters was stronger than that of stress or ovariectomy lonely in mice.The stress and ovariectomy resulted in sleep impairment, the decreasing of the survival time under hypoxia and climbing time on the string, and the increasing of the number of times of the activity in mice.CONCLUSION: The TCM complex I can alleviate the high sensitivity to the environment in mice with ovariectomy and stress, which is similar to the mechanism of human climacteric syndrome.

Key words: stress, ovariectomy, activity, climacteric syndrome

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