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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (10): 1143-1146.

• 研究原著 • 上一篇    下一篇

一种白僵菌代谢产物BCEF0083对慢性应激抑郁大鼠下丘脑、垂体精氨酸加压素含量及海马GRmRNA表达的影响

阚红卫, 程燕, 周兰兰, 明亮   

  1. 安徽医科大学药理教研室, 合肥 230032, 安徽
  • 收稿日期:2005-07-29 修回日期:2005-09-14 发布日期:2020-11-23
  • 通讯作者: 明亮,女,教授,博士生导师,研究方向:神经药理学。Tel:0551-5161133 Email:mingliang410@163.com
  • 作者简介:罗慧英,女,在读博士,研究方向:植物活性成分的研究。Tel:13309483290 E-mail:louria-luo@sina.com
  • 基金资助:
    安徽省科扶厅自然科学基金资助课题(No44415)

Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoidreceptor MRNA of hippocampus in chronic unpredictable stress model ofdepression in rats

KAN Hong-wei, CHENG Yan, ZHOU Lan-lan, MING Liang   

  1. Department of Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China
  • Received:2005-07-29 Revised:2005-09-14 Published:2020-11-23

摘要: 目的: 研究一种白僵茵代谢产物(BCEF0083) 对实验性慢性应激抑郁大鼠下丘脑、垂体精氨酸加压素(AVP)含量及海马糖皮质激素受体mRNA(GR mRNA)表达的影响。方法: 采用慢性不可预见性应激法造成大鼠抑郁模型,用放射免疫分析法测定抑 郁模型大鼠下丘脑、垂体AVP含量,采用逆转录-聚合酶链反应(RT-PCR)法测定海马GR mRNA表达。结果: BCEF0083可降低慢性应激抑郁大鼠下丘脑、 垂体AVP含量,上调海马GR mRNA表达。结论: BCEF0083的抗抑郁作用可能与其降低慢性应激大鼠下丘脑、垂体AVP含量及上调海马GR mRNA 表 达有关。

关键词: 慢性应激, 白僵菌, 精氨酸加压素, 糖皮质激素受体

Abstract: AIM: To study the effect of bioactive compounds from Entomogenous ungl(BCEF0083), on AVP content of hypothalamus, piry and expression glucocorticoid receptor (GR) MRNA of hippocampus in chronic unpredictable stress model of depression in rats.METHODS: The depression animal model was induceby chronic unpredictable stress. The effect of BCEF0083 on AVP content in hypothalamus and pituitary was tested by radioimmunoassay. RT-PCR was used to test the expression of GR MRNA in hippocampus.RESULTS: BCEF0083 decreased the AVP content of hypothalamus and pituitary in chronic unpredictable stressed rats, an dincreased the expression of GR MRNA of hippocampus inchronic stressed rats.CONCLUSION: BCEF0083 ex-hibits antidepressant effect by attenuating the stimulatedfunction of hypothalamus-pituitary-adrenal axis in chronicunpredictable stress model of depression in rats.

Key words: chronic stress, entomogenous fungi, AVP, glucocorticoid receptor

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