木樨草素对小鼠实验性溃殇性肠炎影响

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (10): 1152-1155.

木樨草素对小鼠实验性溃殇性肠炎影响

周祝成, 刘保林, 吴巍巍

中国药科大学中药药理教研室, 南京 210038, 江苏

收稿日期:2005-07-08 修回日期:2005-09-15 发布日期:2020-11-23
作者简介:周祝成,男,硕士研究生,主要从事中药药理和免疫药理研究。

Effect of luteolin on ulcerative colitis in mice

ZHOU Zhu-cheng, LIU Bao-lin, WU Wei-wei

Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Narying 20038, Jiangsu, China

Received:2005-07-08 Revised:2005-09-15 Published:2020-11-23

摘要/Abstract

摘要： 目的: 观察木樨草素对小鼠急性结肠炎的药效作用。方法: 2,4-二硝基氯苯(DNCB)／乙醇灌肠制作小鼠急性结肠炎模型,灌肠给予木樨草素(1、10、50 mg•kg^-1),考察木樨草素对小鼠结肠季占膜组织形态损伤,以及结肠组织髓过氧化物酶(MPO)活力和前列腺素E₂(PGE₂) 含量等的影响。结果: DNCB诱发结肠炎后,小鼠出现腹泻、充血、i责扬、肠壁增库等变化。灌肠给予木樨草素后,对小鼠的腹泻、组织损伤等有显著改善,并且能够降低结肠组织中MPO活性和PGE₂的含量。结论: 木樨草素抑制炎性浸润、渗出和组织增生,减轻结肠季占膜的病理损害,对实验性动物急性结肠炎有较好的治疗作用。

关键词: 木樨草素, 渍殇性结肠炎, 髓过氧化物酶(MPO), 前列腺素E₂(PGE₂)

Abstract: AIM: To evaluate the effect of luteolin onulcerative colitis in experimental animals.METHODS: The mouse model of acute colitis was induced by instillation of dinitrochlorobenzene (DNCB)/alcohol. Luteolin(1, 10 and 50 mg·kg^-1 were orally administrated tomice for 3 days. Dartheas, colon weight index, macro-scopic damage in the colon were observed and the activityof MPO and the content of PGE, in colon were also examined.RESULTS: The diarrhea and the colon weight in dex were reduced and the macroscopic damage in the inflammatory colon was effectively attenuated by luteolinThe elevated level of MPO and PGE₂ were also significantly decreased.CONCLUSION: Luteolin can effectively inhibit the inflammatory infiltration, bleeding andproliteration in experimental ulcerative colitis.

Key words: luteolin, ulcerative colitis, myeloperox-idase (MPO), prostaglandin E₂(PGE₂)

中图分类号:

R965.1

周祝成, 刘保林, 吴巍巍. 木樨草素对小鼠实验性溃殇性肠炎影响[J]. 中国临床药理学与治疗学, 2005, 10(10): 1152-1155.

ZHOU Zhu-cheng, LIU Bao-lin, WU Wei-wei. Effect of luteolin on ulcerative colitis in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1152-1155.

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