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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (4): 361-366.

• 综述 •    下一篇

药动学-药效学结合模型的研究进展

赵刚, 田长青, 李静   

  1. 山东省医学科学院药物研究所,济南 250062,山东
  • 收稿日期:2005-02-05 修回日期:2005-04-14 出版日期:2005-04-26 发布日期:2020-11-19
  • 通讯作者: 赵刚,男, 博士, 副主任药师, 主要从事控释制剂的研究。Tel:0531-6676821  E-mail:Zhaogangcnjn@yahoo.com.cn

Research advances of pharmacokinetic-pharmacodynamic model

ZHAO Gang, TIAN Chang-qing, LI Jing   

  1. Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 250062, Shandong, China
  • Received:2005-02-05 Revised:2005-04-14 Online:2005-04-26 Published:2020-11-19

摘要: 本文主要对近年来药动学-药效学结合模型在模型建立、药理学、毒理学、临床应用及新药研发等方面的进展进行了综述, 并展望其发展前景。

关键词: 药动学, 药效学, 药动学-药效学模型, 临床试验

Abstract: In this article we reviews, the recent ad-vances of pharmacokinetic-pharmacodynamic model reviews in building model and the application in pharmacol-ogy, toxicology, clinical trials, and predicts the development of the PK-PD model in the future.

Key words: pharmacokinetics, pharmacodynamics, pharmacokinetic-pharmacodynamic model, clinical trial

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