糖尿病肾病中转化生长因子-β1 信号转导与肾纤维化

摘要/Abstract

摘要： 糖尿病肾病是终末期肾衰的主要原因之一, 其主要病理特征为肾纤维化, 转化生长因子-β₁ 是其肾纤维化过程中的核心因子。转化生长因子-β₁ 下游的两条信号通路Smads、MAPK 与肾纤维化过程中ECM 的堆积密切相关。两种信号通路相互作用, 共同促进肾纤维化的发展。真正理解它们之间的关系为糖尿病肾病的治疗提供了一个新的思路。

关键词: 糖尿病肾病, 转化生长因子-β₁, 肾纤维化, Smads, MAPK

Abstract: Diabetic nephropathy is one of the leading causes of the end-stage renal failure, and its major patho-logic feature is the renal fibrosis.Transforming growth factor-β₁ is a key factor in the progression of the disease. Two signal pathways, Smads and MAPK following the fac-tor, are closely connected with extracellular matrix accu-mulationwhich leads to renal fibrosis.Smads and MAPK also have a cross talk in extracellular matrix accumula-tion.The relationship between the two signal pathway and ECM accumulation offers us a new therapeutic strategy for renal fibrosis of diabetes.

Key words: diabetic nephropathy, transforming growth factor-β₁, renal fibrosis, Smads, MAPK

中图分类号:

R966

汪建云, 印晓星. 糖尿病肾病中转化生长因子-β₁ 信号转导与肾纤维化[J]. 中国临床药理学与治疗学, 2005, 10(4): 371-376.

WANG Jian-yun, YIN Xiao-xing. Relationship between transforming growth factor-β₁ signal transduction and renal fibrosis of diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(4): 371-376.

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糖尿病肾病中转化生长因子-β₁ 信号转导与肾纤维化

Relationship between transforming growth factor-β₁ signal transduction and renal fibrosis of diabetes

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