模拟失重大鼠骨丢失及血循环状态紊乱的中药防护

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (4): 407-412.

模拟失重大鼠骨丢失及血循环状态紊乱的中药防护

董颀, 沈羡云¹, 谢励勤¹, 孟京瑞¹, 姜世忠¹, 杨光华¹

广州医学院生理教研室, 广州 510182, 广东;
¹航天医学工程研究所, 北京 100094

收稿日期:2004-12-29 修回日期:2005-01-21 出版日期:2005-04-26 发布日期:2020-11-19
通讯作者: 沈羡云,女, 研究员, 博导, 研究方向:失重生理学。Tel:010-66362279 E-mail:shenxy68@tom.com
作者简介:董颀, 女, 硕士, 助理研究员, 研究方向:循环生理学。Tel:020-81340199 E-mail:dongqistar@hotmail.com
基金资助:
国家 863 计划资助项目(NO8632324)

Chinese herb compounds meliorate bone loss and abnormity of blood cir-culation in rats under simulated weightlessness

DONG Qi, SHEN Xian-yun¹, XIE Li-qin¹, MENG Jing-rui¹, JIANG Shi-zhong¹, YANG Guang-hua¹

Department of Physiology, Guangzhou Medical College, Guangzhou 510182, Guangdong, China;
¹Institute of Space Medico-Engineering, Beijing 100094, China

Received:2004-12-29 Revised:2005-01-21 Online:2005-04-26 Published:2020-11-19

摘要/Abstract

摘要： 目的: 观察 4 组中药合剂对尾吊大鼠血液流变学参数、骨质和生物力学特性变化的防护作用。方法: 采用大鼠头低位 30°尾部悬吊模型模拟失重对机体的影响。120 只SD 雄性大鼠随机分为 6 组:对照组、悬吊对照组、丹黄刺组(尾吊同时给予丹参、黄芪和刺五加生药的水煎剂) 、参川熟组(尾吊同时给予川芎生药、熟地和人参地上苷的水煎剂) 、参山杜组(尾吊同时给予西洋参、山楂、杜仲生药的水煎剂) 、参银生组(尾吊同时给予人参根、银杏叶、生地的水煎剂)。实验 30 d, 经心脏取血, 取股骨和椎骨,检测大鼠血液流变学参数、骨矿盐含量、皮质面积和生物力学参数等指标。结果: 单纯尾吊导致大鼠体重、骨皮质面积、矿盐含量、生物力学参数等显著降低, 并使大鼠血液中切与低切血粘度、血浆纤维蛋白原含量、异形红细胞比例显著增加, 红细胞变形性DImax 、IDI 明显下降等。中药合剂组与悬吊对照组相比, 血液流变学指标均有较大改善, 对部分骨生物力学参数也有作用。结论: 中药合剂对模拟失重导致的骨丢失及血循环状态紊乱有一定的防护作用。

关键词: 模拟失重, 血液流变学参数, 骨丢失, 防护

Abstract: AIM: To investigate the role of Chinese herb medicine in improving the changes of bone mass, bone biomechanical properties and hemorheological pa-rameters under simulated weightlessness.METHODS: 120 ratswere divided into 6 groups:control group, head down tilts -30°group (HDT), Danhuangci group (HDT +Dansheng, Huangqi, Ciwujia), Shenchuanshu group (HDT + ginseng, Chuanxiong, Shudi), Shenshandu group (HDT + American ginseng, Haw, Duzhong), and Shenyingsheng group (HDT +ginseng, the leaves of gingkgo, Shengdi). The bone mineral content, bone biomechanical properties and hemorheological parameters were observed following HDT for 30 days.RESULTS: After 30 day HDT, the body weight of rats, content of bone mineral salt, biomechanical indices, and the area of cortex decreased. The blood viscosity in low and middle shear, plasma fibrinogen and the rate of erythrocytes with abnormal shape increased significantly, and erythrocyte deformability (DImax, IDI) and hematocrit (HCT) de-creased.Chinese herb medicines were available to im-prove the hemorheological parameters and some bone biomechanical indices.CONCLUSION: Chinese herb medicines are effective to prevent the changes of blood circulation and bone properties under simulated weight-lessness.

Key words: simulated weightlessness, hemorheologi-cal parameters, bone loss, countermeasure

中图分类号:

R285.5

董颀, 沈羡云, 谢励勤, 孟京瑞, 姜世忠, 杨光华. 模拟失重大鼠骨丢失及血循环状态紊乱的中药防护[J]. 中国临床药理学与治疗学, 2005, 10(4): 407-412.

DONG Qi, SHEN Xian-yun, XIE Li-qin, MENG Jing-rui, JIANG Shi-zhong, YANG Guang-hua. Chinese herb compounds meliorate bone loss and abnormity of blood cir-culation in rats under simulated weightlessness[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(4): 407-412.

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