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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 485-488.

• 综述 • 上一篇    下一篇

氧化应激和阿尔茨海默病

黄艳 综述, 董志 审校   

  1. 重庆医科大学药理教研室, 重庆 400016
  • 收稿日期:2005-03-04 修回日期:2005-04-19 出版日期:2005-05-26 发布日期:2020-11-19
  • 通讯作者: 董志,男, 博士, 教授, 博士生导师, 主要从事神经药理学研究。Tel:(0)13508393231 E-mail:zhidong073@hotmail.com
  • 作者简介:黄艳, 女, 硕士研究生, 主要从事神经药理学研究。Tel:(0)13594048200

Oxidative stress and Alzheimer's disease

HUANG Yan, DONG Zhi   

  1. Department of Pharmacology, Chongqing Medical University, Chongqing400016, China
  • Received:2005-03-04 Revised:2005-04-19 Online:2005-05-26 Published:2020-11-19

摘要: 阿尔茨海默病(Alzheimer's disease, AD)是一种以进行性认知功能障碍和记忆力损害为主的中枢神经系统退行性疾病, 该病是由多种因素共同作用引起的,其中自由基损伤在发病机理中起重要作用。据报道, 抗氧化剂在延缓 AD 病的进程和改善认知能力上有一定疗效。本文就氧化应激自由基损伤与AD的关系以及抗氧化剂研究现状作一综述。

关键词: 药理学, 氧化应激, 阿尔茨海默病, 自由基, 抗氧化剂

Abstract: Alzheimer's disease (AD)is a kind of neuro-degenerative disease mainly affecting both cognition and behavior, and pathologically characterized by deposi-tion of amyloid-beta peptides as senile plaques and by the occurrence of neurofibrillary tangles (NFT).AD is corre-lated with many factors, there are several hypotheses about AD, and one of them is oxidative stress and some anti-oxidative drugs demonstrated effective. This paper reviewed the relation between oxidative stress and AD, and the recent study on anti-oxidative drugs for AD.

Key words: oxidative stress, Alzheimer's disease, free radical, anti-oxidative drugs

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