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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 567-569.

• 研究原著 • 上一篇    下一篇

小檗碱对豚鼠左心房和气管的作用

戴长蓉, 罗来源   

  1. 三峡大学护理学院药理教研室, 宜昌 443000, 湖北
  • 收稿日期:2004-09-20 修回日期:2004-12-27 出版日期:2005-05-26 发布日期:2020-11-19
  • 通讯作者: 戴长蓉, 女,高级讲师, 硕士, 研究方向主要为心血管药理。Tel:0717-8586609   E-mail; der650313 @163.com

Effects of berberine on left atria and trachea in guinea pigs

DAI Chang-rong, LUO Lai-yuan   

  1. Department of Pharmacology, Nursing College, Three GorgesUniversity, Yichang 443000, Hubei, China
  • Received:2004-09-20 Revised:2004-12-27 Online:2005-05-26 Published:2020-11-19

摘要: 目的: 观察小檗碱(berberine, Ber) 对豚鼠左心房和气管的作用。方法: 采用离体豚鼠左心房和气管条实验, 比较 Ber 与吡那地尔(pinacidil, Pin) 的作用。结果: Ber 呈浓度依赖性的增强左房收缩张力, 而 Pin 则浓度依赖性的减弱左房收缩张力。Ber使氨甲酰胆碱(carbachol, Car) 抑制左房收缩的累积量效曲线平行右移, 最大反应(E max) 基本不变, 而 Pin使Car 量效曲线左移;当两药同时存在时, 量效曲线同对照组基本相同。在豚鼠气管, Ber 使乙酰胆碱(acetylcholine, ACh) 累积量效曲线左移, 而 Pin 则使其右移, E max 不压低, 当两药同时存在时, 量效曲线同对照组基本相同。结论: Ber 对钾通道有阻滞作用。

关键词: 小檗碱, 吡那地尔, 左心房, 气管, 量效曲线

Abstract: AIM: To observe the effects of berberine (Ber) on left atria and trachea in guinea pigs. METHODS: The experiment was carried out with isolated left atria and trachea in guinea pigs, and the effects and in-teractions were compared between Ber and pinacidil (Pin). RESULTS: Ber concentration-dependent in-creased the force of contractile, while Pin decreased the force. Ber leaded a parallel rightward shift in accumulated response curve of depression contraction of left atria by Car, and it hardly changed the maximum response (E max), while Pin leaded a parallel leftward shift in the same curve.In the combination of Ber and Pin, the dose-response curve hardly changed as the control one. In iso-lated guinea pig trachea, Ber caused a leftward shift in the dose-response curve of ACh, whereas Pin produced a rightward shift in the same curve without changing E max. When both Ber and Pin existed in the same container, there was no modification in the response to ACh.CONCLUSION: Ber shows the effect of blocking potassium channel.

Key words: berberine, pinacidil, left atria, tra-chea, dose-response curve

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