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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 570-573.

• 研究原著 • 上一篇    下一篇

苦参素胶囊联合复方丹参滴丸治疗乙肝后肝纤维化的临床研究

汪长生, 许慧阳, 蒯荟芬   

  1. 皖南医学院弋矶山医院感染科, 芜湖 241000, 安徽
  • 收稿日期:2005-02-22 修回日期:2005-03-17 出版日期:2005-05-26 发布日期:2020-11-19
  • 通讯作者: 汪长生,男, 主治医师, 医学硕士, 主要从事病毒性肝炎的诊断与治疗的研究。Tel:(0) 13956200834 E-mail:wangchangsh@sina.com

Clinical evaluation on marine capsules combined with the composite Salvia miltiorrhiza dropping pill in treatment of patients with cirrhosis related to chronic hepatitis B

WANG Chang-sheng, XU Hui-yang, KUAI Hui-fen   

  1. Department of InfectiousDiseases, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2005-02-22 Revised:2005-03-17 Online:2005-05-26 Published:2020-11-19

摘要: 目的: 观察苦参素胶囊联合复方丹参滴丸对慢性乙肝肝纤维化的治疗效果。方法: 54 例慢性乙肝肝纤维化患者随机分为对照组和联合治疗组, 观察治疗前、后肝功能、肝纤维化指标和 HBV 标志物的变化。结果: 治疗后联合治疗组各项指标均较治疗前及对照组有明显改善(P<0.05 或 P<0.01)。结论: 苦参素胶囊联合复方丹参滴丸可明显控制乙肝患者的肝脏炎症, 显著提高抗肝纤维化作用, 可抑制HBV 复制且无严重不良反应。

关键词: 乙肝, 苦参素胶囊, 复方丹参滴丸, 肝纤维化

Abstract: AIM: To investigate the therapeutic ef-fects of the marine capsules combined with composite Salvia miltiorrhiza dropping pill in treatment with patients with hepatic fibrosis related to chronic hepatitis B. METHODS: 54 patients were enrolled and randomly di-vided into control group and treatment group.The liver function, the marker of hepatic fibrosis and hepatitis B virus were determined before and after therapy. RESULTS: The markers in this study were significantly im-proved than those before treatment and those in control group (P<0.05 or P<0.01). CONCLUSION: The marine capsules combined with composite Salvia miltior-rhiza dropping pill can effectively control the activity of liver inflammation in the patients with chronic hepatitis B and markedly heighten the effects in treatment of patients with hepatic fibrosis and inhibit the replication of HBV without severe side effect.

Key words: chronic hepatitis B, marine capsules, composite Salvia miltiorrhiza dropping pill, hepatic fibro-sis

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