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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (6): 601-603.

• 综述 •    下一篇

神经病理性疼痛动物模型及其评价

刘国凯, 黄宇光, 罗爱伦   

  1. 中国医学科学院中国协和医科大学北京协和医院麻醉科, 北京100730
  • 收稿日期:2004-08-27 修回日期:2004-12-17 出版日期:2005-06-26 发布日期:2020-11-12
  • 通讯作者: 黄宇光, 男, 教授, 博士生导师, 研究方向:疼痛的实验研究和临床。Tel:010-65295580 E-mail: Huangyg@csc.pumch.ac.cn
  • 作者简介:刘国凯, 男, 在读博士, 研究方向:疼痛机制。Tel:010-65295580 E-mail: liouguokai@yahoo.com.cn。罗爱伦, 女, 教授, 博士生导师, 中华麻醉学杂志主编。
  • 基金资助:
    国家自然科学基金资助项目(NO30371370)

Animal models of neuropathic pain

LIU Guo-kai, HUANG Yu-guang, LUO Ai-lun   

  1. Department of Anesthesiology, Peking UnionMedical College Hospital, PekingUnion Medical College &Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2004-08-27 Revised:2004-12-17 Online:2005-06-26 Published:2020-11-12

摘要: 对神经病理性疼痛发病机制的研究大多来源于动物模型;尽管模型还存在不少缺点, 但是它为理解和探索人类神经病理性疼痛的发病机制提供了有用的工具。动物模型的缺点是动物无法语言交流,对动物的疼痛测量多基于主观行为反应, 比如测量痛敏和异常痛敏。最常用的动物模型包括坐骨神经慢性压迫模型和坐骨神经部分损伤模型等, 通过测量神经损伤侧肢体脚爪皮肤的感觉阈值即主要通过测评对热、机械刺激痛敏(hyperalgesia)和冷、触异常痛敏(allodynia)来确定模型是否成功。

关键词: 神经病理性疼痛, 背跟神经节, 动物模型, 坐骨神经

Abstract: Although there are a number of shortcomings with these animal models, they provide important clues in understanding the underlying pathophysiology of neuropathic pain in humans. In these models, cutaneous sensory threshold of the hindlimb ipsilateral to nerve injury is measured. The presence of neuropathic pain in experimental animal models is mainly measured as allodynia or hyperalgesia, in which the normally nonnoxious or mildly noxious stimuli induce a nociceptive behavioral response. This paper mainly discusses the recent findings from the peripheral nerve injury model of neuropathic pain, as well as the different characteristics of these animal models of neuropathic pain.

Key words: neuropathic pain, dorsal root ganglia, animal model, sciatic nerve

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