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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (8): 932-934.

• 研究原著 • 上一篇    下一篇

黄芪多糖及其与白芍总苷协同对兔血小板聚集功能的影响

魏毅, 刘婷婷1, 林婷婷1, 刘玉银1, 苏小明1   

  1. 广州医学院药理教研室, 广州 510182, 广东
  • 收稿日期:2005-05-19 修回日期:2005-07-08 发布日期:2020-11-22
  • 通讯作者: 魏毅,男,硕士,讲师,研究方向:中药心血管药理。Tel:020-81340203 E-mail:weiyike@21cn.com

Effects of Astragalus polysaccharide and total glucosides of paeony on synergistic antiplatelet aggregation in rabbits

WEI Yi, LIU Ting-ting, LIN Ting-ting, LIU Yu-yin, SU Xiao-ming   

  1. Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, Guangdong, China
  • Received:2005-05-19 Revised:2005-07-08 Published:2020-11-22

摘要: 目的: 研究黄芪多糖(Astragaluspolysaccharide,APS)对血小板聚集功能的作用,并探索其与白芍总苷(totalglucosidesofpaeony,TGP)最佳剂量配比。方法: 比浊法测量家兔血小板聚集功能;用均匀设计两因素五水平的实验安排方法观察黄芪多糖和白芍总苷的最佳配伍剂量。结果: 黄芪多糖对二磷酸腺苷(ADP)引起的血小板聚集有抑制作用(P<0.01),其与白芍总苷的最佳配伍剂量为12∶1。结论: 黄芪多糖和白芍总苷对血小板聚集有协同抑制作用,为中药复方的临床应用提供药理学基础。

关键词: 黄芪多糖, 白芍总苷, 血小板聚集, 均匀设计, 协同作用

Abstract: AIM: To study the interaction effects of Astragalus polysaccharide (APS) and total glucosides of paeony(TGP) with various dosage on the platelet aggregation.METHODS: Platelet aggregation was estimated by the turbidimetric method.The best interaction effects were determined by uniform design method.RESULTS: APS showed apparent anti-platelet effects and better combination with TGP, and the ratio of 12 ∶1 was the best one.CONCLUSION: APS concerted with TGP inhibits platelet aggregation.

Key words: Astragalus polysaccharide, total glucosides of paeony, platelet aggregation, uniform design, synergistic action

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