血管内皮依赖性超极化因子的研究进展

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (10): 1087-1091.

血管内皮依赖性超极化因子的研究进展

范一菲, 孔德虎, 陈志武¹, 高杉¹

安徽医科大学生理学教研室;
¹药理学教研室, 合肥 230032, 安徽

收稿日期:2006-05-11 修回日期:2006-06-23 出版日期:2006-10-26 发布日期:2020-11-05
作者简介:范一菲, 女, 讲师, 硕士研究生, 研究方向:心血管药理学。Tel:0551-3642299 　E-mail:fanyifei10@yahoo.com.cn;陈志武, 男, 博士生导师, 研究方向:心脑血管药理学。Tel:0551-5161133 　E-mail:wzcxiong@mail.hf.ah.cn
基金资助:
本课题由安徽省人才专项基金资助(No2005z031) 及安徽医科大学基金资助(No2005KJ07)

Recent advances in study of endothelium-dependent hyperpolarizing factor

FAN Yi-fei, KONG De-hu, CHEN Zhi-wu, GAO Shan¹

Department of Physidogy ;
¹Department of Pharmaology , Anhui Medical University , Hefei 230032 , Anhui , China

Received:2006-05-11 Revised:2006-06-23 Online:2006-10-26 Published:2020-11-05

摘要/Abstract

摘要： 内皮依赖性超极化因子(endothelium-dependent hyperpolarizing factor, EDHF) 是血管平滑肌内皮源性舒张反应中通过非环氧合酶、非一氧化氮合酶途径的舒张因子。在不同物种、不同血管, EDHF 反应都得到了确认。其在心血管生理学和药理学方面有着重要的作用。

关键词: 内皮依赖性超极化因子, 血管舒张, K⁺通道

Abstract: Besides cyclooxygenase and nitric oxide synthase, another distinct endothelial pathway, endothelium-dependent hyperpolarization factor (EDHF) , is involved in relaxation of the vascular smooth muscle cells.EDHF has been demonstrated unequivocally in various blood vessels from different species, including human,and is likely to play an important role in cardiovascular physiology and pharmacology.

Key words: endothelium-dependent hyperpolarization factor, vasodilatation, potassium channels

中图分类号:

R969
R966

范一菲, 孔德虎, 陈志武, 高杉. 血管内皮依赖性超极化因子的研究进展[J]. 中国临床药理学与治疗学, 2006, 11(10): 1087-1091.

FAN Yi-fei, KONG De-hu, CHEN Zhi-wu, GAO Shan. Recent advances in study of endothelium-dependent hyperpolarizing factor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(10): 1087-1091.

参考文献

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