DNA 甲基化与肿瘤诊断

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (2): 131-135.

DNA 甲基化与肿瘤诊断

吴仲南 ,周向军 ,王永祥

上海交通大学药学院分子药理学实验室, 上海 200030

收稿日期:2005-11-07 修回日期:2005-12-22 出版日期:2006-02-06 发布日期:2020-10-26
通讯作者: 王永祥, 通讯作者, 男, 教授, 博士生导师, 研究方向:系统药理学。 Tel:021-34202763 E-mail:yxwang@sjtu.edu.cn E-mail:yxwang@sjtu.edu.cn
作者简介:吴仲南, 女, 硕士研究生在读, 研究方向:分子药理学。 Tel:021-34202772 E-mail:zhnwu@sjtu.edu.cn 王永祥, 通讯作者, 男, 教授, 博士生导师, 研究方向:系统药理学。 Tel:021-34202763 E-mail:yxwang@sjtu.edu.cn
基金资助:
上海市科委重大科技攻关项目资助课题(№04DZ19211)

DNA methylation and tumor disease

WU Zhong-nan , ZHOU Xiang-jun , WANG Yong-xiang

Laboratory of Molecular Pharmacology , School of Pharmacy , Shanghai Jiao Tong University , Shanghai 200240 , China

Received:2005-11-07 Revised:2005-12-22 Online:2006-02-06 Published:2020-10-26

摘要/Abstract

摘要： DNA 甲基化异常是人类肿瘤中常见的表观遗传变化之一, 伴随着肿瘤的发生和发展,且该异常现象在肿瘤患者的外周循环血清、血浆和尿液等体液中都可检测到。因此, 利用 DNA 甲基化分析技术检测体液中特定分子 DNA 甲基化水平是肿瘤早期诊断、病程监控和疗效评估的潜在手段 ,对临床肿瘤的诊治意义重大。

关键词: DNA 甲基化, 二核苷酸胞嘧啶岛 , 表观遗传, DNA 甲基转移酶 , 肿瘤诊断

Abstract: Abnormal methylation of DNA in certain genomic regions is a frequent epigenetic alteration that is involved in Human tumorigenesis and development .Vari- ous studies have shown that this aberrant DNA modifica- tion can be detected in body fluids of tumor patients, e . g .circulating blood , sputum , urine .So the evaluation of DNA methylation in these body fluids by methylaion de- tection methods can be utilized as a potential biomarker for early cancer detection and accurately clinical assess . This plays a significant role in cancer diagnosis and treat- ment .

Key words: DNA methylation , CpG island , epige- netics , DNA methyl-transferase , tumor diagnose

中图分类号:

R730 .49

吴仲南 , 周向军 , 王永祥. DNA 甲基化与肿瘤诊断[J]. 中国临床药理学与治疗学, 2006, 11(2): 131-135.

WU Zhong-nan , ZHOU Xiang-jun , WANG Yong-xiang. DNA methylation and tumor disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(2): 131-135.

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