关键词: 高血压 , 炎症, 心肌纤维化 , 血管重构

Abstract: Inflammatory processes appear to play an important role in the pathogenesis of cardiovascular dis- eases.It has been established that inflammation has a pivotal role in the atherosclerosis .As a major risk factor contributed to atherosclerosis, hypertension seems to be a chronically low-grade inflammation process .Lots of stud- ies suggested that blood pressure elevation is significantly positive correlation with the levels of inflammatory medi- ators, such as C-reactive protein .Inflammation may pro- mote the process of hypertension .Furthermore, inflamma- tion is highly associated with cardiac fibrosis and vascular remodeling in hypertension .Current clinical trials, for example, ASCOT-LLA suggested that use atorvastatin to reduce the inflammatory reaction in hypertensive patients with normal concentration of cholesterol would decrease the major cardiovascular events ( relative risk reduction 36 %) .This paper summarizes the association inflamma- tion with hypertension as well as cardiac fibrosis and vas- cular remodeling, and tries to explore the clinical signifi- cance of the association .

Key words: hypertension , inflammation , cardiac fi- brosis , vascular remodeling