银杏达莫与舒血宁对老龄大鼠血浆超氧化物歧化酶 、丙二醛和一氧化氮含量及血液流变学的影响

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (5): 582-585.

银杏达莫与舒血宁对老龄大鼠血浆超氧化物歧化酶、丙二醛和一氧化氮含量及血液流变学的影响

路华, 栾家杰, 宋建国¹

皖南医学院弋矶山医院药剂科,¹皖南医学院中药定量药理研究室, 芜湖 241001, 安徽

收稿日期:2006-03-14 修回日期:2006-04-11 出版日期:2006-05-26 发布日期:2020-12-09
通讯作者: 宋建国, 男, 博士, 教授, 硕士导师, 研究方向:定量药理。 Tel:0553-3932581 　E-mail:luanjiajie @hotmail.com
作者简介:路华, 女, 副主任药师, 主要研究方向:临床药理学。 Tel:13866385629 　E-mail:luanjiajie757@medmail.com.cn

Influence of Yinxingdamo injection and Shuxuening injection on hemorhe-ology and plasma levels of superoxide dismutase, malondialdehyde and ni-trogen monoxidum in aged rats

LU Hua, LUAN Jia-jie, SONG Jian-guo¹

Department of Pharmacy, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China; ¹Laboratory of Quantitative Pharmacology, Wannan Medical College, Wuhu 241001, Anhui, China

Received:2006-03-14 Revised:2006-04-11 Online:2006-05-26 Published:2020-12-09
Contact: GUO Rui-chen, male, professor, doctorate tutor, en-gaged in clinical pharmacology. Tel:0531-82169636 　 E-mail:grc7636@126.com

摘要/Abstract

摘要： 目的: 比较银杏叶提取物制剂(ginkgo bilobo extract, EGB) 舒血宁及银杏达莫对老龄大鼠血浆超 (过) 氧化物歧化酶(SOD) 、丙二醛(MDA) 、一氧化氮 (NO) 含量及血液流变学的影响。 方法: 24 只老龄大鼠随机分为 4 组:对照组、银杏达莫组、舒血宁组和双嘧达莫组, 分别给予生理盐水、银杏达莫、舒血宁和双嘧达莫, 各组动物分别腹腔注射相应药物, 给药容量均 2 ml·kg^-1, 每日 1 次, 连续用药 7 d。另 6 只正常大鼠作为正常对照。测定血液流变学指标及血浆 SOD、MDA、NO 的含量。结果: 银杏达莫组与对照组相比, 血浆 SOD 显著升高(P<0.05), MDA 含量显著降低(P<0.01), 全血粘度值(高切) 和纤维蛋白原含量明显降低(P<0.05);舒血宁组与对照组相比, 血浆SOD显著升高(P<0.05), 全血粘度值 (高切) 、全血粘度值(低切) 和纤维蛋白原含量等均明显降低(P<0.05);双嘧达莫组与对照组相比, 纤维蛋白原明显降低(P<0.01), 红细胞变形指数明显升高(P<0.05), 血浆 SOD 和 MDA 含量虽有改变, 但差异均无统计学意义;各用药组血浆 NO 含量均降低, 但无统计学意义。银杏达莫组与舒血宁组相比, 对老年大鼠血液流变学指标及血浆 SOD, MDA 和NO 含量的影响无明显差别(P >0.05)。 结论: 舒血宁、银杏达莫对老年大鼠血液流变学指标均有改善作用, 并升高老年大鼠血浆 SOD, 降低 MDA 的含量, 提示两药均具有抗衰老, 抗氧化, 扩张冠脉血管、脑血管, 改善脑缺血症状的作用。

关键词: 银杏叶提取物, 双嘧达莫, 老年大鼠, 超氧化物歧化酶, 丙二醛, 一氧化氮, 血液流变学

Abstract: AIM: To compare Yinxingdamo injection with Shuxuening injection on hemorheology and plasma levels of superoxide dismutase (SOD), malondialdehyde (MDA) and nitrogen monoxidum (NO) in aged rats. METHODS: 24 aged rats were randomly divided into 4 groups:control, Yinxingdamo group, Shuxuening group and dipyridamole group.The ratswere givenNS, Yinxing-damo injection, Shuxuening injection and dipyridamole, respectively.The administration dosages were 2 ml·kg^-1, once everyday for 7 d successively.Another six normal young rats were arrayed into normal control.Hemorheolo-gy and plasma levels of SOD, MDA and NO were mea-sured.RESULTS: After intraperitoneal injection of Yinxingdamo for 7 days, the level of SOD in plasma of aged rats increased (P<0.05) and the level of MDA de-creased (P<0.01), the whole blood viscosity (at high shear rate) and contents of fibrinogen decreased (P<0.05) compared with those of control group.The level of SOD in plasma of aged rats increased obviously (P<0.05), the whole blood viscosity (at high or lower shear rate) and content of fibrinogen decreased (P<0.05) in Shuxuening group compared with those in control group. After intraperitoneal injection of dipyridamole injection, content of fibrinogen decreased (P<0.01) and index of red blood cell deformation increased (P<0.05) com-pared with those of control group.Plasma NO contents showed a tendency to decrease, but there was no signifi-cant statistical difference between either two groups. There was also no obvious difference on hemorheology and levels of SOD, MDA andNO in plasma between Yinxing-damo group and Shuxuening group (P >0.05).CONCLUSION: Changes of hemorheology in aged rats can be improved with Yinxingdamo or Shuxuening, the level of SOD increases and the level of MDA decreases.The re-sults suggest that the two drugs have effects of anti-aging, anti-oxidation, dilating coronary vessels and cerebral ves-sels and improving the symptom of cerebral ischemia, which may be the pharmacological foundation of prevent-ing and treating high-incidence diseases among aged peo-ple of these two drugs.

Key words: ginkgo bilobo extract, dipyridamole, aged rat, SOD, MDA, NO, hemorheology

中图分类号:

路华, 栾家杰, 宋建国. 银杏达莫与舒血宁对老龄大鼠血浆超氧化物歧化酶、丙二醛和一氧化氮含量及血液流变学的影响[J]. 中国临床药理学与治疗学, 2006, 11(5): 582-585.

LU Hua, LUAN Jia-jie, SONG Jian-guo. Influence of Yinxingdamo injection and Shuxuening injection on hemorhe-ology and plasma levels of superoxide dismutase, malondialdehyde and ni-trogen monoxidum in aged rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(5): 582-585.

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