Toll 样受体4 的研究及现状

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (1): 19-22.

Toll 样受体4 的研究及现状

赵保胜, 霍海如, 姜廷良

中国中医科学院中药研究所唐氏中药研究中心, 北京 100700

收稿日期:2006-08-16 修回日期:2006-10-11 出版日期:2007-01-26 发布日期:2020-10-26
通讯作者: 霍海如, 女, 教授, 博士研究生导师, 研究方向:中药药理学。Tel:010-64041008 　E-mail:hrhuo@sohu.com
作者简介:赵保胜, 男, 博士研究生, 助理研究员, 研究方向:中药药理学。

Advancement of toll-like receptor 4

ZHAO Bao-sheng, HUO Hai-ru, JIANG Ting-liang

Tang Center for HerbalMedicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2006-08-16 Revised:2006-10-11 Online:2007-01-26 Published:2020-10-26

摘要/Abstract

摘要： Toll 样受体4(Toll-like receptor 4, TLR4)是天然免疫系统识别病原微生物的主要受体, 在天然免疫反应中具有重要的作用。TLR4 细菌脂多糖(lipopolysaccharide, LPS)是介导信号跨膜转导的主要受体, 对于革兰氏阴性菌的感染性炎症至关重要。近年来, 有关TLR4 介导的信号转导及其TLR4 与疾病的关系受到人们的关注。本文就TLR4 的信号转导、TLR4 与LPS 的关系进行了综述, 并介绍了TLR4与相关疾病之间的关系, 对TLR4 的研究意义进行了肯定。

关键词: Toll 样受体4, 天然免疫, 信号转导, 感染性炎症

Abstract: Toll-like receptors are main receptors for the innate immune system to recognize pathogenic microorganisms and thus educe very important effect in the innate immune reactions. Toll-like receptor 4 (TLR4)is one of the major receptors which mediates the signal' s transmembrane transduction, and is of great important to the infective inflammation caused by Gram-negative bacteria.Recently, more and more researchers paid close attention to TLR4 and its signal transduction mechanisms. This review describes the signaling transduction of TLR4, the relationships between TLR4 and lipopolysaccharide(LPS), TLR4 and diseases, confirms the significance of TLR4 research.

Key words: toll-like receptor 4, innate immune system, signal transduction, infective inflammation

中图分类号:

R962

赵保胜, 霍海如, 姜廷良. Toll 样受体4 的研究及现状[J]. 中国临床药理学与治疗学, 2007, 12(1): 19-22.

ZHAO Bao-sheng, HUO Hai-ru, JIANG Ting-liang. Advancement of toll-like receptor 4[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(1): 19-22.

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