药代动力学和药效动力学中数学建模与模拟的基本原理(1)

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (1): 82-89.

药代动力学和药效动力学中数学建模与模拟的基本原理(1)

黄晓晖¹, 史军², 李俊¹, 谢海棠³, 郑青山⁴, 孙瑞元³

¹浙安徽医科大学药学院, 合肥 230032, 安徽;
²Forest Laboratories, Inc.,New Jersey 07311,USA;
³安徽省药物临床评价中心, 芜湖 241001, 安徽;
⁴上海中医药大学药物临床研究中心, 上海 201203

收稿日期:2006-12-12 修回日期:2007-01-15 出版日期:2007-01-26 发布日期:2020-10-26
作者简介:黄晓晖, 男, 博士, 副教授, 硕士生导师, 研究方向:数学药理学和临床药代动力学。Tel:13855183138 E-mail:mathdrug@sina.com

Pharmacokinetic-pharmacodynamic modeling and simulation:concepts and basic principles(1)

HUANG Xiao-hui¹, SHI Jun², LI Jun¹, XIE Hai-tang³, ZHENG Qing-shan⁴, SUN Rui-yuan³

¹Center of Pharmacokinetics, College of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China;
²Forest Laboratories, Inc., New Jersey 07311, USA;
³Clinical Drug Evaluation Center of Anhui Province, Wuhu 241001, Anhui, China;
⁴Center of Clinical Drug Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received:2006-12-12 Revised:2007-01-15 Online:2007-01-26 Published:2020-10-26

摘要/Abstract

摘要： 数学建模与模拟(modeling and simulation,M&S)是药代动力学(药动学)与药效动力学(药效学)中重要的定量研究方法, 在研究药物的处置和作用的机理、治疗药物监测及新药开发中发挥越来越重要的作用。但目前国内该领域的研究尚不多, 有待大力发展。另外,M&S 涉及的数学知识较多, 造成研究者阅读文献和实际应用的困难。本系列文章简要介绍M&S 的一些基本概念及重要原理, 供读者参考。本部分着重说明了数学模型的定义、特点、分类, 以及建模解决实际问题的基本思路。

关键词: 药代动力学, 药效动力学, 数学模型, 模拟

Abstract: Modeling and simulation (M&S)is an important research field in pharmacokinetics and pharmacodynamics.M&S has evolved from a tool primarily applied to therapeutic drug monitoring to one that plays a significant role in drug development.Technological advances in various fields related to drug development call for more focus on ways to optimize current drug development practices.Recognition of the potential of M&S by regulatory agencies inevitably has a substantial impact on drug development.The objective of the current review is to present some of the basic concepts and principles of M&S.Case studies are presented to illustrate how M&S can facilitate knowledge management and decision making.In this article, introduction, definitions and background information of M&S are discussed.

Key words: pharmacokinetics, pharmacodynamics, mathematical model, modeling and simulation

中图分类号:

R911

黄晓晖, 史军, 李俊, 谢海棠, 郑青山, 孙瑞元. 药代动力学和药效动力学中数学建模与模拟的基本原理(1)[J]. 中国临床药理学与治疗学, 2007, 12(1): 82-89.

HUANG Xiao-hui, SHI Jun, LI Jun, XIE Hai-tang, ZHENG Qing-shan, SUN Rui-yuan. Pharmacokinetic-pharmacodynamic modeling and simulation:concepts and basic principles(1)[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(1): 82-89.

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