重组人生长激素对局灶性脑缺血大鼠神经功能恢复的影响

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (11): 1288-1291.

重组人生长激素对局灶性脑缺血大鼠神经功能恢复的影响

李榕, 罗春霞, 迟路湘

第三军医大学西南医院神经内科, 重庆市介入脑血管病学研究所, 重庆400038

收稿日期:2007-04-27 修回日期:2007-07-06 发布日期:2020-11-04
通讯作者: 迟路湘, 男, 博士, 副教授, 副主任医师, 主要从事缺血性脑血管疾病介入诊断和治疗方面的研究。Tel:023-68754118
作者简介:李榕, 女, 在读硕士, 主要从事缺血性脑血管病的基础与临床研究。Tel:13637967270 E-mail: lir413@163.com

Effects of the recombinant human growth hormone on recovery of nervous function with focal cerebral ischemia in rats

LI Rong, LUO Chun-xia, CHI Lu-xiang

Department of Neurology,Shouthwest Hospital,Third Military Medical University,Chongqing Interventional Institute of Cerebrovascular Disease, Chongqing 400038,China

Received:2007-04-27 Revised:2007-07-06 Published:2020-11-04

摘要/Abstract

摘要： 目的: 研究重组人生长激素(recombinant humangrowth hormone, rhGH) 对大鼠局部脑缺血损伤后的影响。方法: 应用线栓法制作SD 大鼠大脑中动脉永久性闭塞模型(middle cerebral artery occlusion,MCAO),观察rhGH 对大鼠脑缺血后脑梗死面积和神经功能(网屏试验、平衡木试验、触觉刺激试验) 恢复的情况。结果: 皮下注射rhGH 后, 药物干预组大鼠脑梗死体积较缺血对照组明显减小(P<0.05), 神经功能恢复水平高于自然恢复组。结论: rhGH 能减轻大鼠脑缺血MCAO 后的脑实质和神经功能损伤。

关键词: 重组人生长激素, 脑缺血, 神经功能

Abstract: AIM: To investigate the effects of the recombinant human growth hormone (rhGH) on the recovery of nervous function with focal cerebral ischemia in rats. METHODS: The middle cerebral artery occlusion (MCAO) model was established by insertion of nylon thread in SD rats. The rhGH was given to the rats in the rhGH-treated group. The infarct size and recovery of nervous function were observed after MCAO. RESULTS: The infarct size in the rhGH-treated group (29±5) % was obviously smaller than that in the simple ischemia group (36±4) %.The recovery of nervous function in the rhGH-treated group was much better than that in the simple ischemia group. CONCLUSION: It is manifested that the rhGH can significantly reduce the injure of brain tissue and recover nervous function caused by cerebral infarction.

Key words: recombinant human growth hormone, cerebral ischemia, nervous function

中图分类号:

R965.2

李榕, 罗春霞, 迟路湘. 重组人生长激素对局灶性脑缺血大鼠神经功能恢复的影响[J]. 中国临床药理学与治疗学, 2007, 12(11): 1288-1291.

LI Rong, LUO Chun-xia, CHI Lu-xiang. Effects of the recombinant human growth hormone on recovery of nervous function with focal cerebral ischemia in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(11): 1288-1291.

参考文献

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