糖皮质激素受体介导的胰岛素抵抗及其拮抗剂研究进展

摘要/Abstract

摘要： 糖皮质激素(GC) 是维持机体能量代谢平衡的重要激素之一。GC 作用于靶组织, 不仅有赖于循环中的GC 浓度, 还与糖皮质激素受体(GR) 的表达相关。外源性及内源性的GC 水平升高均会导致机体出现胰岛素抵抗以及与之紧密相关的多种代谢综合征症候, 如血脂障碍、内脏性肥胖和高血压。本文对近年来GR 介导的胰岛素抵抗及其受体拮抗剂的研究进展进行综述。

关键词: 糖皮质激素, 糖皮质激素受体, 胰岛素抵抗, 糖皮质激素受体拮抗剂

Abstract: Glucocorticoids are among those most important hormones that maintain the energy metabolic homeostasis within body.The actions of glucocorticoids on target tissues, such as liver and adipose tissue, are not only dependent on circulating glucocorticoid levels but also on glucocorticoid receptor expression.The elevated level of circulating glucocorticoid caused by exogenous or endogenous reasons may contribute to insulin resistance and the other metabolic syndrome such as dyslipidemia, visceral obesity and hypertension.This review summarizes recent advances in the study of glucocorticoid receptormediated insulin resistance and its antagonists.

Key words: glucocorticoid, glucocorticoid receptor, insulin resistance, glucocorticoid receptor antagonist

中图分类号:

R587.1

梁迎, 丁启龙. 糖皮质激素受体介导的胰岛素抵抗及其拮抗剂研究进展[J]. 中国临床药理学与治疗学, 2007, 12(2): 147-151.

LIANG Ying, DING Qi-long. Advances in study of glucocorticoid receptor induced insulin resistance and its antagonists[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(2): 147-151.

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