西洛他唑对脑缺血后神经元损伤的保护作用

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (5): 535-539.

西洛他唑对脑缺血后神经元损伤的保护作用

陈丽萍^1,2, 叶夷露³, 史文珍¹, 王梦令¹, 张纬萍¹, 魏尔清¹

¹浙江大学医学院药理学教研室,杭州 310058,浙江;
²衢州学院医学系药理学教研室,衢州 324000,浙江;
³浙江医学高等专科学校,杭州 310053,浙江

收稿日期:2006-06-29 修回日期:2007-02-09 发布日期:2020-10-29
通讯作者: 魏尔清,男,博士生导师,研究方向:神经药理。Tel:0571-88208224 E-mail:weieq2004@yahoo.com.cn
作者简介:陈丽萍,女,本科,副教授,研究方向:神经药理。Tel:13957007207 E-mail:yeyilu1006@126.com

Effect of cilostazol on neuronal injury after focal cerebral ischemia in mice

CHEN Li-ping^1,2, YE Yi-lu³, SHI Wen-zhen¹, WANG Meng-ling¹, ZHANG Wei-ping¹, WEI Er-qing¹

¹Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China;
²Department of Pharmacology, Medical Faculty, Quzhou College, Quzhou 324000, Zhejiang, China;
³Department of Pharmacology, Zhejiang Medical College, Hangzhou 310053, Zhejiang, China

Received:2006-06-29 Revised:2007-02-09 Published:2020-10-29

摘要/Abstract

摘要： 目的: 观察西洛他唑对小鼠持续性局灶性脑缺血后神经元损伤的剂量依赖性保护作用。方法: 以大脑中动脉阻塞诱导小鼠持续性局灶性脑缺血。缺血前30 min 腹腔注射西洛他唑(3 ~ 30mg/kg)和普鲁司特(0.1mg/kg)。观察药物对缺血后神经元形态、密度的影响。结果: 脑缺血损伤后,神经元密度降低,变性神经元密度增加。西洛他唑(3 ~10mg/kg)和普鲁司特能明显增加缺血侧存活神经元密度,减少变性神经元密度。结论: 西洛他唑对小鼠持续性局灶性脑缺血后神经元损伤有保护作用。

关键词: 西洛他唑, 脑缺血, 神经元, Fluoro-Jade B染色

Abstract: AIM: To determine the protective effect of cilostazol on neuronal injury after persistent focal cerebral ischemia in mice. METHODS: Persistent focal cerebral ischemia was induced by middle cerebral artery occlusion. Cilostazol (3-30 mg/kg) and pranlukast (0.1mg/kg) were i. p. injected 30 min before ischemia. The changes in the morphology and the densities of neurons and degenerated neurons were determined 24 h after ischemia. RESULTS: After ischemia, neuron density was reduced and the degenerated neurons were increased. Cilostazol (3,10 mg/kg) and pranlukast significantly increased the neuron density and reduced the degenerated neurons in the ischemic hemisphere. CONCLUSION: Cilostazol has protective effect on neuronal injury after persistent focal cerebral ischemia in mice.

Key words: cilostazol, cerebral ischemia, neurons, Fluoro-Jade B stain

中图分类号:

R971.4
R965

陈丽萍, 叶夷露, 史文珍, 王梦令, 张纬萍, 魏尔清. 西洛他唑对脑缺血后神经元损伤的保护作用[J]. 中国临床药理学与治疗学, 2007, 12(5): 535-539.

CHEN Li-ping, YE Yi-lu, SHI Wen-zhen, WANG Meng-ling, ZHANG Wei-ping, WEI Er-qing. Effect of cilostazol on neuronal injury after focal cerebral ischemia in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(5): 535-539.

参考文献

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