血清胸腺因子抗EAC 瘤、H22 瘤、W256 瘤作用的初探

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (6): 668-671.

血清胸腺因子抗EAC 瘤、H22 瘤、W256 瘤作用的初探

张长平¹, 乐嘉静², 李湛君², 徐康森²

¹南京医科大学, 南京210029, 江苏;
²中国药品生物制品检定所, 北京100050

收稿日期:2007-03-10 修回日期:2007-05-16 发布日期:2020-11-09
通讯作者: 徐康森, 男, 硕士, 研究员, 博士生导师, 研究方向:生化药、分子生物学和生化药理等。Tel:010-67095293
作者简介:张长平, 女, 硕士研究生, 研究方向:肿瘤药理。Tel:010-67095568 E-mail:zcp1065@163. com

Initial study on anticancer effect of serum thymic factor

ZHANG Chang-ping¹, LE Jia-jing², LI Zhan-jun², XU Kang-sen²

¹Nanjing Medical University, Nanjing 210029, Jiangsu, China;
²National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

Received:2007-03-10 Revised:2007-05-16 Published:2020-11-09

摘要/Abstract

摘要： 目的:观察血清胸腺因子(FTS) 对荷瘤小鼠的抑瘤作用。方法:荷EAC 瘤小鼠、荷H22 瘤小鼠、荷W256 瘤大鼠分别皮下注射给予不同剂量的FTS, 测定其生命延长率和抑瘤率, 并测定T 细胞增殖能力、迟发型超敏反应等免疫指标。结果:荷EAC、 H22 瘤小鼠注射FTS 0. 25、 0.13 mg/kg 剂量后生命延长率或抑瘤率均大于30%, 生存天数和瘤重与阴性对照组(NS) 比较有统计学差异(P<0. 01); 荷W256 瘤大鼠FTS 各组瘤重与NS 组比较均有统计学差异(P<0. 01), 抑瘤率均大于30% 。另外, 伴刀豆球蛋白A(ConA) 刺激后0. 016 mg/mL 处刺激指数最大。迟发型超敏反应亦呈现阳性结果。结论:FTS 对EAC 瘤、H22 瘤、W256 瘤均具有一定的抑制作用。

关键词: 血清胸腺因子, 抑瘤率, 生命延长率, 免疫增强

Abstract: AIM:To study the inhibitory effect of serum thymic factor (FTS) on cancer cells.METHODS: Bearing cancer mice, rats were administrated with different dosages of FTS. Life extension rate and inhibitory rate were determined. Stimulation index (SI) and delayed hypersensitivity were observed, too.RESULTS:Life extension rate or inhibitory rate in mice exceeded 30% in 0. 25 mg/kg group and 0.13 mg/kg group, and those parameters in rats also exceeded 30% in FTS three groups. After Con-A stimulation, SI achieved maximum at 0. 016 mg/mL.Delayed hypersensitivity also showed positive results.CONCLUSION:FTS has significant inhibitory effect on the growth of EAC, H22 and W256 cancer cells.

Key words: serum thymic factor, inhibitory rate, life extension rate, immunological enhancement

中图分类号:

R965. 2

张长平, 乐嘉静, 李湛君, 徐康森. 血清胸腺因子抗EAC 瘤、H22 瘤、W256 瘤作用的初探[J]. 中国临床药理学与治疗学, 2007, 12(6): 668-671.

ZHANG Chang-ping, LE Jia-jing, LI Zhan-jun, XU Kang-sen. Initial study on anticancer effect of serum thymic factor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(6): 668-671.

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