铁离子在铜绿假单胞菌生物被膜形成中的作用

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (8): 861-864.

铁离子在铜绿假单胞菌生物被膜形成中的作用

蔡芸, 倪淑欣, 梁蓓蓓, 安毛毛, 王睿

解放军总医院临床药理研究室, 北京 100853

收稿日期:2007-04-06 修回日期:2007-05-22 出版日期:2007-08-26 发布日期:2020-10-27
通讯作者: 王睿, 女, 教授, 博士生导师, 研究方向:抗菌药物的合理应用及临床药理学。Tel:010-66939409 E-mail:wangrui301@vip.sina.com
作者简介:蔡芸,女,博士研究生,研究方向:抗菌药物的合理应用。Tel:010-66937909 E-mail:caicaihh@sohu.com

Role of iron in pseudomonas aeruginosa biofilm formation

CAI Yun, NI Shu-xin, LIANG Bei-bei, AN Mao-mao, WANG Rui

Department of Clinical Pharmacology, PLA General Hospital, Beijing 100853, China

Received:2007-04-06 Revised:2007-05-22 Online:2007-08-26 Published:2020-10-27

摘要/Abstract

摘要： 铜绿假单胞菌由于形成生物被膜引发的难治性感染已成为医院亟待解决的问题之一。本文综述了近期关于铁离子与生物被膜形成的相关性的研究报道, 从细菌吸附、小集落的形成、集落发育成熟, 到最后解吸附四个过程阐述了铁离子可能产生的影响。并探讨了对临床应用抗生物被膜局部铁喷雾或者螯合剂治疗的前景。

关键词: 生物被膜, 铜绿假单胞菌, 铁离子

Abstract: The infection caused by pseudomonas aeruginosa biofilm has becoming one of the most urgent problems in hospital.Recent reports of possible mechanism of iron in biofilm formation were reviewed in this paper.The possible effects of iron on adsorption, microcolony formation, mature of colony and desorb were explained, and the prospect of clinical use of local iron or chelator spray was also reviewed here.

Key words: biofilm, pseudomonas aeruginosa, iron

中图分类号:

R969

蔡芸, 倪淑欣, 梁蓓蓓, 安毛毛, 王睿. 铁离子在铜绿假单胞菌生物被膜形成中的作用[J]. 中国临床药理学与治疗学, 2007, 12(8): 861-864.

CAI Yun, NI Shu-xin, LIANG Bei-bei, AN Mao-mao, WANG Rui. Role of iron in pseudomonas aeruginosa biofilm formation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(8): 861-864.

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