过氧化物增殖物活化受体γ辅激活因子1的生理作用及其与2型糖尿病的关系

摘要/Abstract

摘要： 过氧化物增殖物活化受体γ辅激活因子1(peroxisome proliferator activated receptor γcoactivator-1, PGC-1) 是一种辅激活因子, 通过与核受体或非核受体转录因子结合, 共同激活靶基因的转录与表达。PGC-1 的靶基因是能量代谢, 糖、脂代谢等生理过程的关键基因, 因而对正常的能量平衡起着重要的调节作用。最近的研究表明PGC-1的遗传多态性与2 型糖尿病的发生密切相关, 有可能成为一个新的治疗靶点。

关键词: 过氧化物增殖物激活受体γ辅激活因子1, 基因多态性, 能量代谢

Abstract: Peroxisome proliferator activated receptorγcoactivator-1 (PGC-1) is one of the coactivators which binds to nuclear receptors or non-nuclear receptor transcription factors and coactivates the transcription and expression of target genes. Some target genes mediated by PGC-1 are vital genes for energy and glucose lipid metabolism and they play very important role in regulation of normal energy balance in human body. Recently, some studies showed that the genetic polymorphisms of PGC-1 were associated with the development of type 2 diabetes, which possibly makes it as a new candidate target gene in the treatment of patients with type 2 diabetes.

Key words: peroxisome proliferator activated receptorγcoactivator-1, genetic polymorphism, energy metabolism

中图分类号:

R587.1

张可汗, 刘昭前. 过氧化物增殖物活化受体γ辅激活因子1的生理作用及其与2型糖尿病的关系[J]. 中国临床药理学与治疗学, 2008, 13(1): 6-10.

ZHANG Ke-han, LIU Zhao-qian. Physiological action of peroxisome proliferator activated receptor γcoactivator-1 and its relationship with type 2 diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(1): 6-10.

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